Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Promotor: S.M. Verduyn Lunel

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

In this thesis, we show that we can use Shimura’s CM theory to explicitly compute the Hilbert class field of any primitive quartic CM field.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Het Computer Systems, Imagery & Media (CSI) onderzoeksprogramma voert fundamenteel onderzoek uit naar methoden en technieken voor het ontwerp, de implementatie en de applicatie van geavanceerde computersystemen.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

Van systeembiologische modellering een centrale pijler van het onderzoek in de biologie maken.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Promotor: Prof.dr. M. Ubbink

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Lipsius, Cleveringaplaats 1, 2311 BD, Leiden

Promotor: Peter Stevenhagen

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: Prof.dr. S.F. Portegies Zwart

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Promotor: Prof.dr. M. Ubbink

Promotor: S.M. Verduyn Lunel

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.