26 zoekresultaten voor “anticancer” in de Publieke website
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Harnessing the immunostimulatory properties of oncolytic reovirus for anticancer immunotherapy
Promotie
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Masterstudent Maddalena Centanni wint Arenberg-Coimbragroep-prijs
Voormalig masterstudent Bio-Farmaceutische Wetenschappen Maddalena Centanni is dit jaar de winnaar van de Arenberg-Coimbragroep-Prijs voor Erasmusstudenten. Centanni bracht voor haar Erasmus-uitwisseling zes maanden door in Uppsala, Zweden. Hier onderzocht ze manieren om de dosering van anti-kankermedicijnen…
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Analysis of the angucycline biosynthetic gene cluster in Streptomyces sp. QL37 and implications for lugdunomycin production
Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Molecular characterization of copper-dependent enzymes involved in Streptomyces morphology
Promotor: G.P. van Wezel, Co-promotor: D. Claessen
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Computational modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
Promotie
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Text-mining real-world data to evaluate systemic anti-cancer therapy
Promotie
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Nanodeeltjes en licht gaan de strijd aan met kanker
De Leidse promovendus Xuequan Zhou heeft een veelbelovend nieuw molecuul ontworpen dat effectief kankercellen kan bestrijden zonder hierbij ook de gezonde cellen aan te tasten. De truc: het medicijn wordt pas actief als je het bestraalt met licht. Zhou’s nieuwe molecuul is extra efficiënt, aangezien…
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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How to develop cancer drugs with less side effects
Lezing, Tuesday Talks: Science Insights
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Chemicus Sven Askes wint Dick Stufkens Prijs 2017
De Dick Stufkens Prijs 2017 voor het beste proefschrift Holland Research School of Molecular Chemistry (HRSMC) is toegekend aan dr. Sven H.C. Askes. In zijn proefschrift
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Verlichting door licht: dit kankermedicijn vormt zelf nanodeeltjes
Chemotherapie die niet schadelijk is voor het lichaam, maar wel effectief optreedt tegen kankercellen: dat is het doel van de onderzoeksgroep van chemicus Sylvestre Bonnet. Tijdens zijn promotieonderzoek bracht chemicus Xuequan Zhou dat doel een stukje dichterbij. Hij ontwikkelde moleculen die, eenmaal…