117 zoekresultaten voor “selection mutism” in de Publieke website
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Bureaucratic Selection and Politics: Evidence from Teachers in Brazil
Als je ambtenaar wordt, veranderen daarmee jouw politieke opvattingen en gedrag? Hebben leraren in het openbare onderwijs dezelfde normen als andere professionals en de Braziliaanse bevolking als geheel?
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pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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Algorithm selection and configuration for Noisy Intermediate Scale Quantum methods for industrial applications
Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.
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Liposome-based vaccines for immune modulation: from antigen selection to nanoparticle design
Promotie
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oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
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Publicaties
Lees meer over selectief mutisme
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Convergent molecular evolution of toxins in the venom of advanced snakes (Colubroidea)
The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…
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Integrative taxonomy of araneomorph spiders: Breathing new life into an old science
Taxonomy as a science has accumulated data and knowledge for more than 250 years.
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When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Fire and grazers in the West African savanna
Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh
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Adaptive responses to environmental changes in Lake Victoria cichlids
Promotor: M.K. Richardson, Co-Promotor: F. Witte
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Group benefits from genomic instability: a tale of antibiotic warriors in Streptomyces
Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.
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Substrate adaptability of β-lactamase
The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…
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The ecological relevance of chemical diversity in plants
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
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Benchmarking Discrete Optimization Heuristics
This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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Self adjuvanting immunopeptides: Design and synthesis
Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Topics in mathematical and applied statistics
Promotor: A.W. van der Vaart
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A meta-analysis of wetland plant traits in relation to the strategies of wetland plants and the impacts on ecosystem functioning
What are trait-trait relationships in wetlands? To what extent the so-called leaf economics traits deviate from terrestrial ecosystems? How traits specific to wetland plant relate to plant strategies? What’s the relationship between wetland plant traits to the ecosystem functioning (e.g. productivity,…
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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PUMA (Prospecting the Urban Mines of Amsterdam)
PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?
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Reliable and Fair Machine Learning for Risk Assessment
The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.
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Handling missing data, selection bias and measurement error in observational studies
Promotie
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Rechtsgeleerdheid: eLaw
eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Faint Quasars at Very Low Frequencies
In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?
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Evaluation of Different Design Space Description Methods for Analysing Combustion Engine Operation Limits
Promotor: Prof.dr. T.H.W. Bäck
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Soil and crop management options to improve nitrogen cycling on dairy farms on peat soil
The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?
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Data science for tax administration
In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.
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Data-driven Predictive Maintenance and Time-Series Applications
Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.
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LCN2 Seminar: Network model selection via the Minimum Description Length principle: the effects of ensemble non-equivalence
Lezing
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Optimally weighted ensembles of surrogate models for sequential parameter optimization
It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.
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Parallel evolution in an invasive plant species: evolutionary changes in allocation to growth, defense, competitive ability and regrowth of invasive
Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling
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Indicators for "decoupling"
Indicators to measure progress in de-linking economic growth and environmental pressure.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Learning from small samples
Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…
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Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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PhD candidate combinatorial drug discovery with macrocycles
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
- Publicaties
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Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates
We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…
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Research Assistant
Geesteswetenschappen, Instituut voor Geschiedenis
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Postdoc on Law, Robots & Society (0.8-1.0 FTE)
Rechtsgeleerdheid, Instituut voor Metajuridica, eLaw - Centrum voor Recht en Digitale Technologie
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PhD Fellow War peace and Justice
Governance and Global Affairs, Institute of Security and Global Affairs
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KNIR Call Colloquia
The KNIR organises up to three Colloquia each year with no more than fifteen participants. All university lecturers working at an NWIB University can apply for this. The selection of candidates focuses on the quality of the application, on motivation and on the relationship with KNIR, Rome and/or Italy.…
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Postdoc in Comparative Political Economy of Labour Market Risks and Welfare State Transformations
Rechtsgeleerdheid
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eLaw presenteert op het ACM Symposium over computerwetenschap en recht 2024
Op 13 maart 2024 presenteerden op afstand Carlotta Rigotti (postdoctoraal onderzoeker bij eLaw) en Alexandre Puttick (postdoctoraal onderzoeker bij de hogeschool Bern University of Applied Sciences) op het ACM Symposium over computerwetenschap en recht in Boston.
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Publicatie artikel “Bypassing the gatekeeper: incidental negative cues stimulate choices with negative outcomes”
Promovendus Niek Strohmaier heeft een artikel gepubliceerd in het gerenommeerde tijdschrift Cognition & Emotion, met de titel: “Bypassing the gatekeeper: incidental negative cues stimulate choices with negative outcomes”. Dit artikel onderzoekt in brede zin welke factoren van invloed zijn op de keuzes…
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Does knowledge of environmental performance change farmer's behaviour?
Does knowledge of environmental performance change farmer's behaviour?