2,617 zoekresultaten voor “evolution and development” in de Publieke website
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Geometric approach to evolution problems in metric spaces
Promotor: S.M. Verduyn Lunel, Co-promotor: O.W. van Gaans
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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Parallel evolution in an invasive plant species: evolutionary changes in allocation to growth, defense, competitive ability and regrowth of invasive
Promotor: Prof.dr. P.G.L Klinkhamer, Co-promotor: K. Vrieling
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Facets of radio-loud AGN evolution: a LOFAR surveys perspective
Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice
Miriam Cohen verdedigde haar proefschrift genaamd “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” op 28 juni 2017. Ze schreef haar proefschrift onder supervisie van prof.dr. L.J. van den Herik en prof. dr. C. Stahn.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Leukemia treatment & cognitive development
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Emotions and the psychosocial development of children with and without Developmental Language Disorder
Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis
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Development of visual span in Hebrew and Dutch-speaking prereaders
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Digital Media in Human Development (MSc)
De masterspecialisatie Digital Media in Human Development gaat over kansen en uitdagingen van digitale media in opvoeding en onderwijs.
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Applied Neuroscience in Human Development (MSc)
Voor wie geïnteresseerd is in de relatie tussen neuro-cognitieve en biologische factoren enerzijds en leren, gedrag en emoties anderzijds.
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Enquête Sustainable Development Goals onder Onderzoekersers
Het volgende rapport bespreekt onze enquête over de UN Sustainable Development Goals die werd verspreid onder onderzoekers aan de Universiteit Leiden in november 2021.
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: Prof.dr. J.N. Kok
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Convergent molecular evolution of toxins in the venom of advanced snakes (Colubroidea)
The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…
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Antiquities of the rainforest: evolution of mycoheterotrophic angiosperms growing on Glomeromycota
Promotor: Prof.dr. E.F. Smets
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Leiden Consortium on Individual Development (L-CID)
Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?
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Genetic risk & atypical development: 22q11 Syndrome
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- Frugal Innovation for Sustainable Global Development
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Development of a Dynamic Substance Stock Model
Making a dynamic substance stock model in order to conduct scenario analyses and make forecasts.
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Play by the rules? : coordination of EU sustainable development policies and the importance of the politico-legal context
There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…
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Peer feedback in teacher professional development
Dit proefschrift wil een geïntegreerd kader voor de praktijk van peer feedback van leraren bieden, en een diepgaand begrip van peer feedback van leraren in de context van het Chinese beroepsonderwijs.
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Sex effects on development of brain structure and executive functions: Greater variance than mean effects
In dit onderzoek wordt hersenontwikkeling voor het eerst direct gelinkt aan sekseverschillen en schoolprestatie. De resultaten ontkrachten de mythe dat jongens achterlopen in hersenontwikkeling.
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reflective functioning: Influence on parenting practices and the early development of externalizing behavior
Het terugdringen van agressie is in de afgelopen jaren in toenemende mate een maatschappelijke prioriteit geworden. Agressie in de vroege kindertijd vergroot de kans op latere agressieproblemen en antisociaal gedrag.
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Regulation of the arabidopsis AGC kinase PINOID by PDK1 and the microtubule cytoskeleton
Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.
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Development of synthetic procedures towards immunostimulating carbohydrates
Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée
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indigenous institution in the context of sustainable socio-economic development in Indonesia
In times of hardships or crisis, local people know how to deal with it using their resourcefulness. Although efforts are sometimes made by the government to help them, they are fully aware that community support is at least equally important.
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the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement
Op 26 juni 2019 verdedigde Lisa Louwerse haar proefschrift 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. Het promotieonderzoek is begeleid door promotor prof. mr. C.A.P. Hillion.
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The Miliuseae revisited: phylogenetic, taxonomic, and palynological studies in a major clade of Annonaceae
Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Control of early plant development by light quality
This thesis describes how different colours of light affect various aspects of the growth and development of Arabidopsis and tomato plants.
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High-contrast imaging polarimetry of exoplanets and circumstellar disks
Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.
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Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT)
Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)
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Calcium-dependent regulation of auxin transport in plant development
The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Science teachers' knowledge development in the context of educational innovation
Het onderzoek dat in dit proefschrift wordt beschreven gaat over de ontwikkeling van praktijkkennis van ervaren natuurkunde- scheikunde -en biologiedocenten in de context van de invoering van het vak Algemene Natuurwetenschappen (ANW) in de Tweede Fase van het voortgezet onderwijs.
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Bakti and Sayan traditions among the Tenggerese people in East Java: the role of indigenous institutions in integrated elderly care development
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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Life Cycle Assessment-Based Guidance for development of New Energy Technologies
The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.
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Artificial metallo-proteins for photocatalytic water splitting: stability and activity in artificial photosynthesis
Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.