54 zoekresultaten voor “preventing” in de Publieke website
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Computer interventions for young children at risk to prevent reading impairments
This study’s main aim is to test whether children’s learning behaviour explains why they do not benefit from a literate environment.
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Transnational counterterrorism assemblages: the case of preventing and countering violent extremism in Mali
In dit artikel wordt onderzocht hoe de dreiging van terrorisme op beleidsniveau is aangepakt door middel van een analyse van een specifiek in Mali.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Towards in-cell structural study of light-harvesting complexes : an investigation with MAS-NMR
Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.
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Economic value of non-timber forest products among Paser Indigenous People of East Kalimantan
Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh
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Wat werkt bij het voorkomen van sociale angst?
Programma's die de symptomen van sociale angst bij kinderen willen verminderen, omvatten doorgaans meerdere onderdelen, zoals blootstelling en mentale herstructurering. Het is onbekend of afzonderlijke onderdelen positieve effecten opleveren bij kinderen of dat een combinatie van onderdelen nodig is…
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Terrestrial field trials for side-effects of pesticides
The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers
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Abstract delta modeling: software product lines and beyond
Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke
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The origins of friction and the growth of graphene, investigated at the atomic scale
Promotor: J.W.M. Frenken
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Establishing State Responsibility in the Absence of Effective Government
Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Onderwijs
Het onderwijs in Den Haag heeft een sterke basis in het onderzoek. Naast bachelor- en masteropleidingen biedt de universiteit ook aan scholieren, professionals en andere geïnteresseerden mogelijkheden om zich te ontwikkelen.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Spatial populations with seed-bank
In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Onderzoek
Research
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Corruption & Integrity in the Netherlands (1945 - present)
Corruption, integrity (or a lack thereof…) and public values are near omnipresent elements in public administration and politics of all times. Cases of corrupt public officials and politicians continuously emerge. Strangely enough, however, it often remains unknown what actually occurred, how something…
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Rechtsgeleerdheid: eLaw
eLaw onderzoekt de rol van het recht in de informatiemaatschappij: hoe kan het recht bijdragen aan een goede werking van informatie- en communicatietechnologie, en het gebruik ervan door burgers, bedrijven en overheden?
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Bezoek de Leidse voorronde van FameLab
Welke twee Leidse bètawetenschappers presenteren hun onderzoek het aanstekelijkst in drie minuten? Misschien wel degenen met de meeste supporters. Op 14 februari vindt de Leidse voorronde van FameLab plaats. Meld je nu aan als publiek!
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Media over Leidse doorbraak haantjesselectie
Diverse media besteden aandacht aan de nieuwe techniek om het geslacht van kuikens al in het ei te bepalen.
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Joanne Mouthaan wint dissertatieprijs
Psychologe Joanne Mouthaan heeft een Jan van Dijk Victimology and Victims' Rights Award 2015 gewonnen voor de beste dissertatie over slachtoffers en slachtofferhulp.
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Leidse samenwerking ondersteunt ontwikkeling vaccin tegen coronavirus
De afdeling Medische Microbiologie van het Leids Universitair Medisch Centrum (LUMC) gaat de werking onderzoeken van een nieuw experimenteel vaccin tegen het coronavirus. Het onderzoek vindt plaats in samenwerking met het Leidse farmaceutische bedrijf Janssen, de ontwikkelaar van het kandidaat-vaccin.…
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COI Conference 2023: Call for Abstracts
The 2023 Conference: Institutions for Conflict Resolution (COI) aims to identify just institutional approaches that seek (real) conflict prevention and conflict resolution in the legal context. It will be held in Utrecht on 28 and 29 September 2023. We welcome abstracts from all researchers around the…
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Redactie Common Market Law Review kritisch over Brexit-referendumcampagne
Verklaring van de redactie van de Common Market Law Review over de Brexit-referendumcampagne:
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Bitter Sweet Symphony
Promotie
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Research Seminar Series
For questions and suggestions regarding the series, please contact prof. dr. Olaf van Vliet or dr. Max van Lent
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Publicaties
Publicaties die verschijnen in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus.
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Zomerschool over extremisme geeft inkijkje in theorie en praktijk
Iedere zomer is de Universiteit Leiden het toneel van tientallen summerschools waar professionals en studenten zich in korte tijd kunnen laten bijscholen in één onderwerp. We namen een kijkje bij een zomerprogramma over extremisme. ‘Een ronselaar van Al Qaida zei dat ik de wereld kon veranderen.’
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Janssen COVID-19-vaccin goedgekeurd voor gebruik in EU
Het coronavaccin van Janssen-Cilag International N.V. is op 11 maart goedgekeurd door het Europees Geneesmiddelenbureau (EMA). De Moleculaire Virologiegroep van het Leids Universitair Medisch Centrum (LUMC) leverde een belangrijke bijdrage aan de ontwikkeling van het vaccin.
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Prediction of contralateral breast cancer - Statistical aspects and performance assessment
Promotie
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International Law and Indigenous Rights in Australia
Lezing
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The Independence of National Regulatory Agencies
Lezing
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Mass harm in European Private law
Lezing
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Reaching the unreachable: access to legal aid for marginalised people
Lezing
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Voordrachten
Voordrachten in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus (aug. 2017 – dec. 2023).