1,088 zoekresultaten voor “development disease” in de Publieke website
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Understanding disease suppressive soils
Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Macrophage activation and cholesterol in atherosclerosis development
Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
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Macrophage activation and cholesterol in atherosclerosis development
Promotores:Th.J.C. van Berkel, M. van Eck
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Lipids as therapeutic targets for barrier repair in skin diseases
The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.
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metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
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Sustainable Development
This interdisciplinary minor addresses sustainabilty challenges from a systems perspective, and investigates ways to sustain society within planetary boundaries.
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Wiskundig model helpt ontstaan van wervels en ribben te verklaren
Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.
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Test development
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Metabolomics to predict progression in chronic kidney disease
Promotie
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Researcher for development of advanced metabolomics methods
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Law, Culture and Development
Let op: bachelorstudenten van de Faculteit der Rechtsgeleerdheid kunnen vakken uit het eigen curriculum niet opvoeren voor deze minor. Je kunt alleen de gebonden keuzevakken volgen en opvoeren die geen onderdeel uitmaken van je eigen bachelorprogramma.
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Parenting and Child Development (MSc)
Wil je weten welke invloed opvoeding binnen en buiten het gezin heeft op de ontwikkeling van het kind? Kies dan deze specialisatie!
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brain connectivity: pharmacological modulation, aging and Alzheimer's disease
Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer.
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Leukemia treatment & cognitive development
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Nieuwe planten produceren zonder zaaien
Zonder een gewas opnieuw te zaaien toch nakomelingen produceren, die zelfs groter kunnen zijn dan de ouderplant. Volgens Leidse onderzoekers is dat mogelijk door het overstimuleren van één gen. Daarmee verjongt een cel en gaat deze terug naar de embryonale fase.
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Cultural Anthropology and Development Sociology (MSc)
In onze eenjarige masteropleiding leer je hoe je het dagelijks leven van kwetsbare groepen - zowel in Nederland als wereldwijd - kunt bestuderen, en hoe je ze binnen de complexe processen van sociale en globale ontwikkeling kunt plaatsen.
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pharmacology of antimicrobials, towards optimized treatment of infectious diseases in hospitalized patients
Promotie
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Insight into the Pathophysiology of Cardiometabolic Diseases using multiple Omics Approaches
Promotie
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Online Proefstuderen Cultural Anthropology and Development Sociology
Studievoorlichting
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Digital Media in Human Development (MSc)
De masterspecialisatie Digital Media in Human Development gaat over kansen en uitdagingen van digitale media in opvoeding en onderwijs.
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Applied Neuroscience in Human Development (MSc)
Voor wie geïnteresseerd is in de relatie tussen neuro-cognitieve en biologische factoren enerzijds en leren, gedrag en emoties anderzijds.
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Levensverlengend gen bij planten ontdekt
Oogst na oogst binnenhalen van rijstveld, zonder nieuwe rijstplanten te zetten? Door een ontdekking komt dit scenario misschien wel dichterbij. Leidse wetenschappers hebben een gen ontdekt waarmee ze eenjarige planten na het bloeien opnieuw laten groeien, in plaats van dat de planten sterven. Publicatie…
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‘Onbelangrijk’ plantengen blijkt wel degelijk essentieel
Leidse biologen hebben aangetoond dat een gen dat aanwezig is in planten, dieren en gisten wel degelijk een belangrijke rol speelt in planten, al werd daar jaren anders over gedacht. Zonder het gen blijkt de ontwikkeling van vaatweefsel in planten niet goed op gang te komen. Publicatie in Nature Plants…
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Unraveling the broad NOTCH3-associated small vessel disease spectrum: from CADASIL to non-penetrance
Promotie
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Nationalism, Ethnic Conflict and Development (MSc)
Het organiseren van diversiteit is een van de grootste uitdagingen van nu. Etnische, raciale, religieuze en culturele verschillen staan wereldwijd op de agenda, dikwijls omdat deze leiden tot gewelddadige conflicten. In deze masterspecialisatie kijk je waarom en hoe deze conflicten ontstaan en welke…
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Enquête Sustainable Development Goals onder Onderzoekersers
Het volgende rapport bespreekt onze enquête over de UN Sustainable Development Goals die werd verspreid onder onderzoekers aan de Universiteit Leiden in november 2021.