192 zoekresultaten voor “cancer” in de Publieke website
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Regulation of TGF-β signaling and EMT in cancer progression
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Nieuwe hoogleraar wil betere zorg door app voor sarcoompatiënten
Artsen moeten samen met patiënten met bot- en wekedelentumoren op zoek naar een optimale persoonlijke behandelstrategie, vindt prof. dr. Michiel van de Sande. Hij heeft een app ontwikkeld die bij de behandelkeuze ondersteunt. Van de Sande is vanaf 1 mei 2020 benoemd tot Leidse hoogleraar Orthopedie,…
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barriers: unraveling response mechanisms to immunotherapy in breast cancer
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Tumor-specific targets for imaging in vulvar cancer
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Antoni van Leeuwenhoek en LUMC slaan handen ineen voor immuuntherapie
Het eigen afweersysteem van een kankerpatiënt versterken zodat het lichaam zelf beter kankercellen kan vernietigen. Het is de kern van immuuntherapie, de hoopgevendste vooruitgang binnen de behandeling van kanker van de afgelopen jaren. Om deze ontwikkeling verder aan te jagen slaan het Antoni van Leeuwenhoek/Nederlands…
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Therapeutisch vaccin vergroot overlevingskans voor patiënten met baarmoederhalskanker
Patiënten met baarmoederhalskanker hebben een grotere overlevingskans door een therapeutisch HPV-16 vaccin. Een nieuwe studie van het Leidse biotechnologie bedrijf ISA Pharmaceuticals B.V. en het Leids Universitair Medisch Centrum (LUMC) bewijst dat de response van het vaccin versterkt kan worden in…
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Klein molecuul gaat uitzaaien tumorcellen tegen
Leidse chemici wisten met collega’s in York en Israël een molecuul te maken dat de weefselstructuur om een tumor heen steviger houdt. Zo kunnen losse tumorcellen niet zo makkelijk uitzaaien. De onderzoekers hebben al patent op het molecuul aangevraagd, maar gebruik hiervan bij patiënten is nog onzeker.…
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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evaluations of nanocarriers to improve the effectiveness of colorectal cancer treatment
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
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Pancreatic cancer: Chasing the light at the end of the tunnel
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Untangling the immune landscape of colorectal cancer by in situ multiplex immunophenotyping
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Partial Breast Irradiation in elderly patients with early-stage breast cancer
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Immunosuppression in breast cancer: a closer look at regulatory T cells
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Genomic driven treatment and drug rediscovery in patients with advanced cancer
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Systems biology as a compass to understand cancer-immune interactions in humans
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The impact of one: single cell analysis of T cell states in human cancer
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TGF-β signaling dynamics in epithelial-mesenchymal plasticity of cancer cells
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The role of the Bone Morphogenetic Protein Pathway in Colorectal Cancer
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pharmacogenetics of systemic and intraperitoneal chemotherapy in colorectal cancer
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Light therapy for cancer-related fatigue in (non-)Hodgkin Lymphoma Survivors
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Supporting women with breast cancer in making an informed decision about immediate breast reconstruction
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Sexual Health Care in Prostate Cancer for Men and their Partners
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Colorectal cancer screening for average- and high-risk individuals Beyond one-size-fits-all
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Computational modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
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Molecular imaging of pancreatic and rectal cancer - Towards optimized detection and response prediction
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Text-mining real-world data to evaluate systemic anti-cancer therapy
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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The T cell-myeloid axis in the success and failure of cancer immunotherapy
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Molecular approaches to identify cancer T cell antigens and improve immunogenicity
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Targeting MHC-I related proteins for cancer diagnosis and therapy
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Nanoparticle-based combination drug delivery systems for effective cancer treatment
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the response to immunotherapy in patients with non- small cell lung cancer
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Judith Bovée
Faculteit Geneeskunde
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Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
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Nieuwe hoogleraar gaat medicijnen ontwikkelen binnen academische wereld
Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.
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Screening the CITY: Optimizing population-based cancer screening in the Netherlands from a primary care perspective
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