Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

LIBC PUBLIEKSDAG 'HUMAN POTENTIAL; OPTIMALISEER JEZELF, TRAIN JE HERSENEN' (in Dutch)

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Promotor: B.van de Water, Co-promotor: L.S.Price

Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.

Promotie

Het eerste wereldwijde congres over placebostudies van 2-4 april moest uitwijken naar de Stadsgehoorzaal om de deelnemers uit 20 landen te ontvangen. Ook de Nederlandse media lieten zich niet onbetuigd. Bekijk een selectie uit het nieuws met Andrea Evers over placebo's en conditionering.

Onder de gezamenlijke titel ‘Scarcity and the State’ verschenen onlangs twee Engelstalige boeken over de verdeling van schaarse publieke rechten (Intersentia 2016). Paul Adriaanse (UL), Frank van Ommeren (VU), Willemien den Ouden (UL) en Johan Wolswinkel (Tilburg University) voerden de redactie. Aan…

Promotie

Freya Baetens is momenteel gastprofessor aan de National University Singapore (NUS). NUS begon als een medische faculteit in 1905, opgericht door een vastbesloten groep van zakenlui onder leiding van Tan Jiak Kim, om aan de noden van de lokale bevolking tegemoet te komen. Vandaag is NUS het academische…

Op donderdag 7 mei jl. promoveerde Jolanda van der Vliet op haar proefschrift ‘The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach’. De verdediging vond online plaats. Jolanda werkte aan dit proefschrift met begeleiding van het…

Hartje zomer en tóch de collegebanken in? Studenten uit de hele wereld komen naar Leiden en Den Haag voor een summer school. De onderwerpen variëren van taalkunde tot internationaal strafrecht en van natuurkunde tot biofarmacie. Docenten en studenten vertellen over leerzame en leuke momenten.

De Arabische vrouwen komen eraan! Dat is de boodschap van Kim Ghattas op 6 maart in de 25e Annie Romein-Verschoorlezing. Het zal niet makkelijk zijn en het kan lang duren, maar het lukt ze. De Arabische lentes inspireerden hen en dat houden ze vast.

Promotie

Promotie

Vrijdag 13 april 2018 heeft voor de afdeling Jeugdrecht van de Universiteit Leiden in het teken gestaan van het symposium: ‘Deprivation of Liberty of Children in The Justice System – Towards A Global Research Agenda’. Het symposium werd georganiseerd door prof. dr. Ton Liefaard en dr. Yannick van den…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Remus Dame

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.