1,991 zoekresultaten voor “binding study advies bsa” in de Publieke website
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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One million spins as study tools and study objects
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The chlorine chain study
A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.
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Kabinetsvoorstel voor lager bindend studieadvies: geen goed plan
De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.
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Pesticides Atlas, Pilot Study
Description of Atlas of the surfacewater concentrations of pesticides in the Netherlands, a pilotstudy.
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Studying through the summer?
Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…
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Persoonlijk advies
Mocht je nog met bepaalde vragen zitten en je wilt graag met iemand spreken, dan biedt Universiteit Leiden hiervoor verschillende opties.
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…
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Raad van Advies
De taken van de Raad van Advies
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LUF International Study Fund (LISF)
Bachelor, Master
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How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1
The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.
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Raad van advies
Museums, Collections & Society heeft een Adviesraad.
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Binding van rechters aan elkaars uitspraken in bestuursrechterlijk perspectief
Een ambtenaar die wordt vervolgd, kan worden ontslagen ondanks dat hij is vrijgesproken. En soms kan een burger die een vergunning heeft gekregen hier toch geen gebruik van maken zonder onrechtmatig te handelen jegens zijn buurman. Hoe gaat een rechter om met een uitspraak van een collega-rechter?
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Insights into microtubule catastrophes: the effect of end-binding proteins and force
For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.
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EuDEco case study report (D1.3)
D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Synergy Study: Sentinel2 –Sentinel3 Land Products
To deliver a Virtual Sensor tool optimised to exploit the synergy between Sentinels 2 and 3 to allow the consistent retrieval of land surface parameters (Albedo, LAI, and LST); To extend the existing capabilities of land EO data assimilation tools to add capacity to handle data in the thermal domain…
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Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
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Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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SFA of Chlorine in Europe: A MacTempo Case-Study
An overview is given of the flows of chlorine and chlorinated hydrocarbons through the Europian Union.
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The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
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The galaxy–dark matter connection: a KiDS study
In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.
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Dynamical Gibbs-non-Gibbs transitions: a study via coupling and large deviations
Promotores: F.H.J. Redig, W.T.F. den Hollander
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Studierendement LST flink omhoog
Zowel de universiteiten als het ministerie van Onderwijs willen dat studenten op tempo studeren. Hoe zorg je daarvoor? De bacheloropleiding Life Science and Technology heeft de laatste jaren een flinke vooruitgang geboekt.
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Universiteit Leiden past BSA-regeling eerste studiejaar aan en stopt met experiment tweede studiejaar
De Universiteit Leiden stopt per direct met het experiment bindend studieadvies in het tweede studiejaar (BSA-2). Studenten moesten in BSA-2 binnen twee jaar 90 studiepunten halen, inclusief hun propedeuse.
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Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Development of new chemical tools to study the cannabinoid receptor type 2
The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.
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Electroreduction of nitrate and carbon dioxide on copper electrodes: a mechanistic study
In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…
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Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace
Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.
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EU Bank Resolution Framework: A comparative study on the relation with national private law
Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.
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Studying dark matter using weak gravitational lensing : from galaxies to the cosmic web
Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).
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Teachers' perspectives on self-regulated learning: an exploratory study in secondary and university education
Centraal in dit proefschrift staan de perspectieven van docenten met betrekking tot zelfstandig leren.
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The use of activity based protein profiling to study proteasome biology
Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Understanding collaborative governance approaches to ‘big’ problems through studying ‘small’ practices
In dit artikel heeft Lianne Visser bijgedragen aan het begrip rondom samenwerkend bestuur als uitdagende aanpak voor hardnekkige problemen.
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T-CYCLE EPR: Development at 275 GHz for the study of reaction kinetics & intermediates
A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.
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Synthetic peptides, nucleic acids and molecular probes to study ADP-Ribosylation
This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.