Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

The expedition commanded by Nicolas Baudin to Tenerife, Mauritius, Australia, Timor and South Africa in 1800-1804 is fully researched in regard to ornithology.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Can we provide the Dutch government with an integrative framework, wherein the various policies can be placed and the need for further measures can be identified?

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

OB associations are loose groups of young, massive stars. They constitute the last stage of the massive starformation process, and the context in which new stars are formed.

A substance flow analysis, covering about 99 % of the flows of chlorinated substances in the Netherlands.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

Dark matter is one of the biggest mysteries of the Universe. Its properties cannot be explained with the known laws of physics and elementary particles.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Leiden University College The Hague (LUC) biedt een 3-jarige bacheloropleiding aan waarin je je focust op Global Challenges; grote uitdagingen waar de mensheid mee te maken heeft: Vrede & Rechtvaardigheid, Diversiteit, Duurzaamheid en Welvaart. Je hebt ruimte om de opleiding zo in te richten als je…

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Promotor: A.P. IJzerman

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…

Promotor: F.J. van Lunteren, E. Jorin

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

The complexity of an intelligence problem determines to a great extent the certainty that can be provided by intelligence and security services.

The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Naast het feit dat angstproblemen veelvoorkomend zijn en het daarom belangrijk is om hier effectieve preventieve programma’s en behandelingen voor te ontwikkelen, is dat in deze tijd extra relevant.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Promotor: A.P. IJzerman