Zoeken - Universiteit Leiden

Next generation lipopeptide antibiotics Onderzoeksoutput
This thesis describes the evaluation of novel natural products with antibacterial activity enabled by total chemical synthesis.

Next generation bacitracin: reimagining a classic antibiotic Onderzoeksoutput
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance Onderzoeksoutput
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Discovery of antibiotics and their targets in multidrug-resistant bacteria Onderzoeksoutput
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches Onderzoeksoutput
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

The Ecology and Evolution of Microbial Warfare in Streptomyces Onderzoeksoutput
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning Onderzoeksoutput
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems Onderzoeksoutput
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…