3,140 zoekresultaten voor “science and society” in de Publieke website
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Néron models in high dimension: nodal curves, Jacobians and tame base change
We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.
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Signatures of Majorana zero-modes in nanowires, quantum spin Hall edges, and quantum dots
Promotor: Prof.dr. C.W.J. Beenakker
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Bio Science Park levert Leidse regio duizenden banen en miljoenen euro's op
Het Leiden Bio Science Park is niet alleen voor de stad Leiden, maar ook voor de Leidse regio en Nederland als geheel van groot belang. Dat blijkt uit een onderzoek van de Rekenkamercommissie Leiden-Leiderdorp. Dankzij de grote ontwikkeling die het Bio Science Park in de afgelopen jaren heeft doorgemaakt,…
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Impact of nitrogen fertilization on the soil microbiome and greenhouse gas emission
The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Universal adelic groups for imaginary quadratic number fields and elliptic curves
Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)
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The dust and molecular gas in the torus of NGC 1068
An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.
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Non-equilibrium chemistry and cooling in simulations of galaxy formation
Promotor: J. Schaye
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as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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The optimization and scale-up of the electrochemical reduction of CO₂ to formate
Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…
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The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
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Electrocatalysis of CO2/CO interconversion and Hydrogen Evolution in Bicarbonate Buffers
Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.
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Mind the gap: gas and dust in planet-forming disks
Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond
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Soil and crop management options to improve nitrogen cycling on dairy farms on peat soil
The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?
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Innate immunity, developmental speed and their trade-offs in two hexapod models
This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.
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Cosmic particle acceleration by shocks and turbulence in merging galaxy clusters
In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).
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Interview met hoogleraar Data Science Aske Plaat over het belang van data science
Ebola heeft niet alleen een hoop dood en verderf gezaaid, maar heeft ook iets moois opgeleverd. Er is veel vooruitgang geboekt op het gebied van ziektebestrijding en -preventie- nota bene door statistici - die kan helpen bij toekomstige virusuitbraken. 'Iedereen die een beetje in het vakgebied van de…
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Poiesis and the Performance Practice of Physically Polyphonic Notations
Kevin speelt hedendaags repertoire dat zich onderscheidt doordat de lichamelijk handelingen die nodig zijn om deze muziek uit te voeren in de notatie van elkaar losgekoppeld zijn. Dit heet ook wel physical polyphonic notations, een unieke en relatief recente trend in de muziek waarbij naast de noten…
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Probing the darkness: the link between baryons and dark matter
Promotor: Prof.dr. J. Schaye, Co-promotor: Marcello Cacciato
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Online Course International Law in Action: Investigating and Prosecuting International Crime
This course provides an insider perspective into the work of international criminal courts and tribunals. You will learn about the investigation and prosecution of international crimes in The Hague.
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Science & Cinema: Leidse wetenschappers op het Leiden International Film Festival
Een film en quiz in de Oude Sterrewacht, met je mobiel zelf de afloop van de film bepalen, of in Den Haag naar een politieke satire kijken. Het kan allemaal in Science & Cinema, the 444 edition, een speciaal programma tijdens het LIFF, het Leiden International Film Festival.
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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Politics, Culture and National Identities, 1789 to the Present (research) (MA)
De specialisatie Politics, Culture and National Identities, 1789 to the Present (research) van de Universiteit Leiden brengt je in de voorhoede van de nieuwe benadering van de manier waarop in Europa politiek en identiteit worden opgevat.
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Girlsday in het Junior Science Lab
In het kader van Girlsday 2010 organiseerde het Junior Science Lab van de Universiteit Leiden op 22 april een middag voor meiden van middelbareschoolleeftijd. Het doel: laten zien hoe leuk werk en studie in de (bio)chemie zijn.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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The mixed Ax-Lindemann theorem and its applications to the Zilber-Pink conjecture
Promotores: Prof.dr. S.J. Edixhoven, Prof.dr. E. Ullmo (University Paris-Sud)
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Spin-momentum locking in oxide interfaces and in Weyl semimetals
Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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The electrochemical reduction of dioxygen and hydrogen peroxide by molecular copper catalysts
The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…
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multi-objective optimization of software architecture design: method, tool, and application
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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An Online Corpus of UML design models: Construction and empirical studies
Promotores: J. Kok, M. Chaudron (Chalmers University)
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Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
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Sanne Kellij
Faculteit der Sociale Wetenschappen
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Wessel Kraaij
Wiskunde en Natuurwetenschappen
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Ludo Juurlink
Leiden Learning and Innovation Centre
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Michael Meffert
Faculteit der Sociale Wetenschappen
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Laurens van Gestel
Faculteit der Sociale Wetenschappen
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Barend Mons
Faculteit Geneeskunde