3,589 zoekresultaten voor “leiden institute for brain and cognition” in de Publieke website
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
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The music of language: exploring grammar, prosody and rhythm perception in zebra finches and budgerigars
Promotor: C.J. ten Cate
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Onderzoek
Het onderzoek van de sectie Gezondheids-, Medische en Neuropsychologie richt zich op de psychologische aspecten van gezondheid en ziekte, en op het ontwikkelen van innovatieve behandelingen.
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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FAIRDOM – FAIR Sharing for Systems and Synthetic Biology
Het FAIRDOM-consortium is een open initiatief van verschillende partners, waaronder financieringsprogramma's, grote consortia, instituten, kleine groepen en individuen.
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Greek, Demotic and Coptic Papyri and Ostraca in the Leiden Papyrological Institute
Dit boek bevat de eerste edities van 66 papyri en ostraca uit de collectie van het Leids Papyrologisch Instituut.
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Measures and Matching for Number Systems
This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.
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Robust rules for prediction and description.
In this work, we attempt to answer the question:
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Vernieuwde MRI-scanner gereed voor gebruik
Het Leiden Institute for Brain and Cognition (LIBC) neemt op 29 september de vernieuwde MRI-scanner in gebruik. Het apparaat is sneller en beter dan de huidige opstelling.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Heinekenlezing Prof. Michael Tomasello
De KNAW Heinekenprijs voor Cognitiewetenschap wordt dit jaar uitgereikt aan Prof. Michael Tomasello, mededirecteur van het Max Planck Instituut voor Evolutionaire Antropologie in Leipzig. Prof. Tomasello zal de Heinekenlezing, getiteld
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Center for Legal Entrepreneurship and Innovation
Het Center for Legal Entrepreneurship and Innovation (CLEI) richt zich op het stimuleren van ondernemerschap en innovatie in de juridische bedrijfstak.
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Private lessons for guitar and ukelele | English spoken
Kunst en vrije tijd, Kunst en vrije tijd
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Student for a day English Language and Culture
Studievoorlichting
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Student for a day Philosophy: Global and Comparative Perspectives
Studievoorlichting
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Conference: "Senses, Cognition, and the Body" (Padova, 5-7 June)
From 5 to 7 June, the conference "The Senses, Cognition, and the Body in Medieval Devotional Practices" will take place at the University of Padova. The conference programme can be found below. The conference can be attended virtually through the registration link below.
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Algorithm selection and configuration for Noisy Intermediate Scale Quantum methods for industrial applications
Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Novel approaches for direct exoplanet imaging: theory, simulations and experiments
The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.
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LIBC Onderzoeksfaciliteiten
Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):
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Machine learning and computer vision for urban drainage inspections
Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.
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Call for Papers: The Senses, Cognition, and the Body in Medieval Devotional Practices, Padova, 5-6 juni 2024
On 5 and 6 june 2024, the conference The Senses, Cognition, and the Body in Medieval Devotional Practices is organised at the University of Padova. The organisers welcome abstracts for 25-minute papers in English or Italian, to be submitted by November 30.
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Supramolecular polymer materials for biomedical applications and diagnostics
Self-assembly is an abundant process in nature and is vital to many processes in living organisms.
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Lattice models for Josephson junctions and graphene superlattices
In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.
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Algorithms for analyzing and mining real-world graphs
Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Reconstruction Methods for Combined HAADF-STEM and EDS Tomography
The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.
- English Language Assessment for BA and MA students
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
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Intermittency and Number Expansions for Random Interval Maps
This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.
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methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Universiteit Leiden stemt in met garantstelling Open Access taalkunde
Voor de transitie van het taalkundig onderzoek naar Open Access zijn de betrokken universiteiten in VSNU-verband gevraagd zich financieel garant stellen. De universiteiten hebben hiermee ingestemd, zo ook de Leidse.
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Is asylum bad for men (and better for women)? Changing perspectives on female and male refugees and asylum seekers in the Netherlands in the
Deelproject van
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Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Meta-heuristics for vehicle routing and inventory routing problems
Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
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Molecular and Nano-Engineering with Iron, Ruthenium and Carbon: Hybrid structures for Sensing
Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.
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Van data naar inzichten
Sociaal wetenschappelijk onderzoek leert ons om menselijk gedrag en maatschappelijke structuren te begrijpen. Deze worden bepaald door veel verschillende factoren. Dat maakt het onderzoek complex en vergroot de kans op onterechte conclusies. Het kiezen van de onderzoeksmethoden en analyses is dan ook…
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Methods and Tools for Mining Multivariate Time Series
Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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(mixed CO/CO2 streams) into intermediates for polyurethane plastics for rigid foams/building insulation and coatings
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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Reliable and Fair Machine Learning for Risk Assessment
The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.