64 zoekresultaten voor “antigen” in de Publieke website
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Handreiking ex ante evaluatie Contraterrorismebeleid
Joery Matthys, universitair docent aan het Institute of Security and Global Affairs, bracht begin deze maand een ex ante evaluatie van het Contraterrorismebeleid uit.
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Bioorthogonal chemistry to unveil antigen processing events
The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.
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Search for cosmic neutrinos with ANTARES
Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Dyslipidemia, metabolism and autophagy: antigen-independent modulation of T cells in atherosclerosis
Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
- Elastin-like polypeptide micelles for vaccine delivery
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Neutrinos From the Milky Way
Promotor: Prof.dr. M. de Jong
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LIFE-GREENAPI
Het ontwikkelen en demonstreren van innovatieve praktijken om met een lage milieu-impact farmaceutica te produceren.
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Guiding safe and sustainable technological innovation under uncertainty: a case study of III-V/silicon photovoltaics
A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.
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PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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PROGENY
How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.
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Meta-heuristics for vehicle routing and inventory routing problems
Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich
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Sander van Kasteren
Wiskunde en Natuurwetenschappen
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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Carbon4PUR | Turning industrial waste gases (mixed CO/CO2 streams) into intermediates for polyurethane plastics for rigid foams/building insulation
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Real-time foresight: preparedness for dynamic innovation networks
Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer
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Oorsprong van neutrinosignaal blijft mysterie
Natuurkundigen hebben een astrofysisch neutrinosignaal van de IceCube detector bestudeerd vanuit een andere hoek. Het centrum van de Melkweg leek vanzelfsprekende de bron te zijn, maar deze hypothese is nu eerder verworpen dan bevestigd. Publicatie in Physical Letters B.
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Life Cycle Assessment-Based Guidance for development of New Energy Technologies
The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Constraints on large-scale implementation of BioSolarCells, Early stage assessment of environmental value propositions
What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?
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Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: W. Jiskoot, Co-promotor: A. Kros
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Leukemia treatment & cognitive development
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Synthesis and application of glycans unique to S. Mansoni
Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
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Collateral Transactions and Shadow Banking
Op 13 oktober 2021 verdedigde Ross Spence het proefschrift 'Collateral Transactions and Shadow Banking'. Het promotieonderzoek is begeleid door promotoren prof.mr. M. Haentjens en prof.dr. A.M. Pacces (UvA).
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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De werking van algemene belangenafwegingen in het Europese staatssteunrecht: tussen verbod en verenigbaarheid?
Op 5 juni verdedigde Maarten Aalbers het proefschrift 'De werking van algemene belangenafwegingen in het Europese staatssteunrecht: tussen verbod en verenigbaarheid?'. Het promotieonderzoek is begeleid door Pieter van Cleynenbreugel en Stefaan van den Bogaert.
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Jana Enking
Wiskunde en Natuurwetenschappen
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Eerste ontdekking bron van hoogenergetische neutrino’s uit de ruimte
Voor het eerst hebben wetenschappers het spoor van een hoogenergetisch neutrino uit de ruimte herleid tot zijn bron. Het is geproduceerd door een zogeheten blazar, een superzwaar zwart gat. Dat melden onderzoekers van neutrinodetector IceCube in Science. ‘Dit is een mijlpaal voor de neutrinoastronomie,’…
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non-endemic settings by quantification of schistosome circulating anodic antigen
Promotie
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Leiden: Silicon Valley van FAIR data
Als onderzoekers hun data FAIR maken, kunnen computers grote hoeveelheden data koppelen en patronen herkennen waardoor onderzoekers veel sneller tot nieuwe inzichten kunnen komen. In Leiden, de bakermat van FAIR data, legt professor Barend Mons uit wat die term inhoudt.
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Neutrino’s zoeken op de bodem van de Middellandse Zee
Met sensoren op de zeebodem speuren Leidse natuurkundigen naar Neutrino’s om inzicht te krijgen in de werking van deeltjesversnellers. Dat doen zij binnen twee internationale samenwerkingsverbanden; Antares en KM3NeT. Begin mei zijn de eerste sensoren succesvol geïnstalleerd. Dat blijkt uit het licht…
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Hebben banken mensenrechten?
Op dinsdag 1 oktober 2019 ontving het Hazelhoff Centre for Financial Law voor de negentiende Hazelhoff Guest Lecture Paul Sharma, managing director bij Alvarez & Marsal en co-head van praktijkgroep European Financial Industry Regulatory Advisory Services.
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Over het TRIXY Team
Het team van wetenschappers binnen TRIXY Expertisecentrum zorgt ervoor dat belangrijke kennis verzameld wordt over kwetsbaarheden bij deze kinderen.
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Oekraïne moet de oorlog blijven voortzetten totdat alle bezette gebieden zijn bevrijd
'De EU moet niet buigen nu de oorlog langer gaat duren.' Dat schreef Joris Larik, universitair docent Europees recht, in een opiniestuk in het FD (Financieele Dagblad).
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Neutrinotelescoop KM3NeT ontvangt 12,7 miljoen van NWO
KM3NeT is geselecteerd als een van de tien top onderzoeksfaciliteiten in NWO’s