A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Hoe kunnen we met behulp van moleculair gereedschap meer inzicht krijgen in de ziekteverwekkende eigenschappen van de Neisseria pili?

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Professor Paul Hooykaas en Dr. Remko Offringa sleepten namens het IBL de subsidies binnen. Het onderzoek van Hooykaas gaat over het transportsysteem van de bodembacterie Agrobacterium tumefaciens en het onderzoek van Offringa over het proces van somatische embryogenese.

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Promotor: Prof.dr. J.P. Abrahams, Co-Promotor: N.S. Pannu

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Een tropisch vlindertje past zich aan aan zijn omgeving en creëert zo betere overlevingskansen. Dit wordt veroorzaakt door hormoonsignalen, die informatie over de temperatuur doorgeven aan weefsels van de vlinder. Bioloog Ana Rita Mateus laat zien hoe een complex samenspel van omgeving, fysiologie…

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Julie Rutten licht een van haar stellingen bij haar promotie toe. De achtergrond van de stelling is dat ze haar partner ontmoette in het LUMC-laboratorium van humane genetica waar ze haar onderzoek deed. ‘Voor mij was een dergelijke relatie altijd 'no go'.’

Promotores: Prof.dr. F. van Lunteren, Prof.dr. F.S. Gaastra

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Timo Slootweg, associate professor at he department Philosophy of Law, published a chapter about Paul Scholten in

Leeuwen in West- en Centraal Afrika verschillen opvallend van leeuwen in het oosten en zuiden van Afrika. Dat blijkt uit genetisch onderzoek door wetenschappers van het Institute of Environmental Sciences en het Instituut Biologie Leiden. Ze werkten samen met onderzoekers van verschillende universiteiten.…

Dr. Peter J. Punt, werkzaam bij TNO, is benoemd tot bijzonder hoogleraar Industriële Biotechnologie en gaat zich richten op de moleculaire genetica van filamenteuze schimmels.

Je volgt een basispakket van biologievakken, exacte vakken in de informatica en speciale integratievakken.

Deze opleiding integreert genetica, moleculaire biologie en biotechnologie in een aantrekkelijk programma met uitstekende carrièreperspectieven.

Promotor: F.J. van Lunteren, E. Jorin

Als serieuze wetenschapper kun je er niet aan twijfelen: de evolutietheorie. Maar door het woord 'theorie' lijkt evolutie voor het grote publiek slechts een potentiële verklaring die je prima in twijfel kunt trekken. Evolutiebioloog Maurijn van der Zee legt bij Nemo Kennislink uit waarom dat niet zo…

Sinds 2009 behaalden 84 kandidaten hun doctoraat in Creative en Performing Arts. Op deze pagina een overzicht van ACPA's alumni.

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: A. Kros

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotor: P.D. Grünwald

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Promotor: Prof.dr. P. Stevenhagen

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.