Universitaire Bibliotheken Leiden bouwt aan een nieuwe Middle Eastern Library. Leer alles over onze collecties, nieuws, evenementen en de bouw.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Learning from small data sets in machine learning is a crucial challenge, especially when dealing with data imbalances and anomaly detection. This thesis delves into the challenges and methodologies of learning from small datasets in machine learning, with a particular focus on addressing data imbalances…

Promotores: S.F. Portegies Zwart, E. M. Rossi

Promotor: Prof.dr. M. de Jong

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The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Wat doe je als je iets te weten wilt komen? Tegenwoordig gebruikt men voornamelijk het internet om informatie te verkrijgen. Een lezer moet deze informatie vaak uit meerdere bronnen halen en die bronnen met elkaar in verband brengen, om zo een compleet plaatje te vormen van het onderwerp. Soms is de…

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Electoral Systems and Turnout: Evidence From a Regression Discontinuity Design. In dit artikel, gepubliceerd op de website SAGE research methods, bespreken auteurs Jaroslaw Kantorowicz en Tobias M. Hlobil hoe een Regression Discontinuity Design uitgevoerd kan worden.

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: Roeland M.H. Merks

Als je ambtenaar wordt, veranderen daarmee jouw politieke opvattingen en gedrag? Hebben leraren in het openbare onderwijs dezelfde normen als andere professionals en de Braziliaanse bevolking als geheel?

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Promotie

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Since its beginnings, Leiden University has been home to scholars with a broad and diverse expertise in the histories, languages, literatures and material cultures relevant to the study of Jews and Judaism from antiquity to modern times.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

This dissertation presents new cryptographic protocols, which can be divided into two families.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

Empirical Legal Studies in Leiden focust op het bouwen van een interdisciplinaire gemeenschap van rechtsgeleerden en sociale wetenschappers die samen juridische vraagstukken onderzoeken op het snijpunt van recht en gedrag, waarbij diverse soorten methoden worden gebruikt.

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

De Leiden Slavery Studies Association (LSSA) is toegewijd aan het bevorderen van een beter begrip van slavernij en post-slavernij in elke periode en elk geografisch gebied.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr