The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: W. T. F. den Hollander, F. H. J. Redig

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Special Issue in: Visual Anthropology, Volume 29, Issue 3, 2016

In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Promotores: Prof.dr. G.A. van der Marel, M. van Heel

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Nieuwe Duitse vertaling van 'Winnaars en verliezers. Een nuchtere balans van vijfhonder jaar immigratie' from Leo Lucassen and Jan Lucassen.

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

Promotor: K.J. Batenburg, Co-promotor: A.W. van der Vaart, B. de Smit

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotor: Prof.dr. C.W.J. Beenakker

Recentelijk is een Special Issue van de European Journal of Criminology verschenen, die is samengesteld door Marieke Liem, Universitair Docent Criminologie bij het Instituut voor Strafrecht & Criminologie, en William Pridemore.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Solar energy is used by photosynthetic organisms to drive energy required cellular processes. Is absorbed by two groups of pigments, located in the LHCs.

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: Prof.dr. E.F. van Dishoeck

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Including modelling as part of software development appears to have various benefits.

In de tweede helft van de negentiende eeuw groeide Amsterdam uit tot hoofdstad van Nederland. Maar zagen de negentiende-eeuwse Amsterdammers zichzelf ook als Nederlanders? Dit boek laat zien hoe dienstmeisjes en schoenmakers, winkeliers en schooljongens hun Nederlanderschap in het dagelijkse Amsterdamse…

Make use of this time to improve your language skills by signing up for custom-made online language classes.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.