120 zoekresultaten voor “genetics” in de Publieke website
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Molecular Genetics and Biotechnology (MSc)
Deze opleiding integreert genetica, moleculaire biologie en biotechnologie in een aantrekkelijk programma met uitstekende carrièreperspectieven.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Genetic risk & atypical development: 22q11 Syndrome
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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Genetic diversity in the lion (Panthera leo (Linnaeus 1758)): unravelling the past and prospects for the future
Promotor: Prof.dr. G.R. de Snoo
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additional signals on genes: on the combination of DNA mechanics, genetics and translation speed
DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.
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The mechanical genome : inquiries into the mechanical function of genetic information
The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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educational interventions with computer programmes: the influence of genetic and neurobiological factors
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From molecules to monitoring: Integrating genetic tools into freshwater quality assessments
Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.
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Genetic and environmental factors determining heterogeneity in preservation stress resistance of Aspergillus niger conidia
Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.
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Comparative ecology and genetics of sympatric wild cats in relation to human wildlife conflict in Bardia National Park, Nepal
What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…
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Validating the Genetic Alterations in Cutaneous T-cell Lymphoma: Unraveling the Role of SOCS1 and HNRNPK through Genetically Engineered Mouse
Promotie
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Diversity in the globally intertwined giant barrel sponge species complex
This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotor: J.M. Memelink
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Patterns of coral species richness and reef connectivity in Malaysia
Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema
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Anagnostis Theodoropoulos
Wiskunde en Natuurwetenschappen
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Leeuwen in West- en Centraal-Afrika blijken uniek
Leeuwen in West- en Centraal-Afrika vormen een unieke groep, die relatief weinig verwant is met leeuwen in Oost en zuidelijk Afrika. Biologen van de Universiteit Leiden bevestigen dit in een artikel gepubliceerd in Scientific Reports.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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Dormancy in stochastic interacting systems
Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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Genetic and lifestyle factors in breast cancer prognostication
Promotie
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Genetic-Tracing of CD8+ T cell fate decisions
Promotie
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Prior information and variational Bayes in high dimensional statistical network inference
This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).
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Genetics and Life Course Epidemiology of Cardiometabolic Disease
Promotie
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species
The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Spatial populations with seed-bank
In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Unravelling East Africa’s Early Linguistic History (LHEAf)
This project investigates the rich linguistic history of the crucial language groups in East Africa and includes a search for words that indicate earlier lost languages. These outcomes, combined with recent archaeological and genetic research, will contribute to a new understanding of East Africa’s…
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.
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Biology (MSc)
De master Biology is een samenwerking tussen het Instituut Biologie Leiden, Naturalis en het Centrum voor Milieuwetenschappen Leiden waardoor het programma een brede en diverse scope heeft. De opleiding biedt zeven specialisaties, waarvan vier researchspecialisaties die nauw verbonden zijn met het onderzoek…
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Functional analysis of genetic variants in PALB2 and CHEK2
Promotie
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Metagenomics for community ecology; a next generation of eDNA monitoring tool for biomass studies in freshwater environments
How can we quantify the density of species within a community through environmental DNA concentrations?
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
- My DNA and the community: what is the future?
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Wetenschappelijke publicaties
Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.
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Genetic and clinical pharmacology studies in GBA1-associated Parkinson's disease
Promotie
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Using functional genetic screens to understand and overcome PARP inhibitor resistance
Promotie