10,000 zoekresultaten voor “leiden” in de Publieke website
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Beginsel en begrip van verdeling
Op 22 november 2018 verdedigde Teico Sikkema zijn proefschrift 'Beginsel en begrip van verdeling'. Het promotieonderzoek is begeleid door promotoren prof. mr. W.G. Huijgen en prof. dr. F. Sonneveldt.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Inextricable ties between chemical complexity and dynamics of embedded protostellar regions
Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
- Winterbijeenkomst - Generatieve AI
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Het land van Don Quichot
De grotten van Altamira, het Alhambra, het Escoriaal, la Sagrada Familia van Antonio Gaudi, Cervantes’ Don Quichot en de schilderijen van Pablo Picasso: Spanje kent een rijke geschiedenis, die met dit boek tot leven komt voor studenten, toeristen en iedereen die van het land houdt.
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Bearing with noise: The effects of highway noise on behaviour and development in zebra finches
Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.
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China’s industrial carbon emissions: Historical drivers at the regional and sectoral levels and projections in light of policy
This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.
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Ecological functioning of bacterial chitinases in soil
Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)
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Advances in SQUID-detected Magnetic Resonance Force Microscopy
In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).
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Uncovering the ingredients for planet formation
This thesis discusses the physical and chemical processes than influence the composition of forming planets.
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Algebraic techniques for low communication secure protocols
Promotor: R. Cramer
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Spionkoppen: Inlichtingenleiderschap in elf portretten
In Spionkoppen geeft Paul Abels, bijzonder hoogleraar Inlichtingenstudies aan de Universiteit Leiden en zelf oud-inlichtingenman, de diensthoofden een gezicht en een profiel. In elf portretten laat hij zien waar ze vandaan kwamen, hoe ze werden geselecteerd, wat hun stijl van leidinggeven was, hoe ze…
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Algorithms for analyzing and mining real-world graphs
Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters
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Pragmatiek
Woorden kunnen, afhankelijk van wie ze waar en wanneer gebruikt, erg veel verschillende betekenissen hebben of zelfs het tegenovergestelde van hun woordenboekbetekenissen uitdrukken.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Onderzoek
De staf van het Europa Instituut bezit een uitgebreide expertise omtrent het recht van de Europese Unie en de Europese bescherming van de mensenrechten in het algemeen.
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Volatile compounds from Actinobacteria as mediators of microbial interactions
Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.
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Opportunity and Problem in Context (OPiC). A framework for environmental management in developing countries
Promotor: W.T. de Groot
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Effects of the early social environment on song and preference learning in zebra finches
Songbirds as vocal learners learn their songs and song preference from social tutors. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song.
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Using cryo-EM methods to uncover structure and function of bacteriophages
Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.
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When galaxy clusters collide: the impact of merger shocks on cluster gas and galaxy evolution
Promotor: Prof.dr. H.J.A. Rottgering
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Het miljard deeltjes probleem
Promotor: Prof.dr. S. Portegies Zwart
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Wetenschappelijk onderzoek en onderwijs
Het LUBEC is nauw verbonden met de Universiteit Leiden.
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Design and evaluation of video portfolios: reliability, generalizability, and validity of an authentic performance assessment for teachers
In welke mate zijn beoordelingen op basis van een videodossier betrouwbaar, generaliseerbaar en valide?
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Kearifan Kesehatan Lokal: indigenous medical knowledge and practice for integrated nursing of the elderly with cardiovascular disease in Sumedang
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
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Inducing spin triplet superconductivity in a ferromagnet
Promotor: J. Aarts
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Detection, detention, deportation
Op 8 januari 2020 verdedigde Jelmer Brouwer zijn proefschrift 'Detection, detention, deportation'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.P. van der Leun en prof.dr. M.A.H. van der Woude.
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EU H2020 RISE Social Media Analytics
LIACS is a partner in RISE_SMA, an interdisciplinary, international network combining excellent scholars and practitioners to enable vigorous knowledge sharing and to develop solutions for contemporary challenges for Social Media Analytics (SMA).
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Arithmetic of affine del Pezzo surfaces
In this thesis integral points on affine del Pezzo surfaces are studied.
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Mechanical Response of Foams: Elasticity, Plasticity, and Rearrangements
Promotor: M.L. van Hecke
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Diagnosis and treatment of obese children with insulin resistance
Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst
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Guidance documents of the European Commission in the Dutch legal order
Op 11 februari 2020 verdedigde Clara van Dam haar proefschrift 'Guidance documents of the European Commission in the Dutch legal order'. Het promotieonderzoek is begeleid door promotoren prof.dr. W. den Ouden en prof.dr. J.E. van den Brink (UvA).
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On the Power Efficiency, Low latency, and Quality of Service in Network-on-Chip
In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.
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Spinning worlds
Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy
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Erfgoed Gezocht Utrechtse Heuvelrug
Vrijwilligers en archeologen doen samen onderzoek naar nog onontdekt archeologisch erfgoed op de Utrechtse Heuvelrug
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Design, implementation and evaluation of transnational collaborative programmes in astronomy education and public outreach
Promotores: Prof.dr. G. Miley & Prof.dr. J.M. van den Broek
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Anisotropy, multivalency and flexibility-induced effects in colloidal systems
We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.
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(Nieuw) Fascisme
Besmetting, gemeenschap, mythe
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Winds in the AGN environment: new perspectives from high-resolution X-ray spectroscopy
Promotor: J.S. Kaastra Co-promotor: E. Constantini
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Stellar radio beacons for Galactic astrometry
A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.
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PNEC-pro
PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Engagement of citizens and public professionals in the co-production of public services
The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.