818 zoekresultaten voor “international human richt” in de Publieke website
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Musems, Collections and Society | Yearbook 2021
In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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Fuzzy systems and unsupervised computing: exploration of applications in biology
In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.
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Aria of the Dutch North Sea
Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn
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Multi Modal Representation Learning and Cross-Modal Semantic Matching
Humans perceive the real world through their sensory organs: vision, taste, hearing, smell, and touch. In terms of information, we consider these different modesalso referred to as different channels of information or modals.
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Aspects of Record Linkage
Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft
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Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. It is the main cause of birch pollen allergy in humans.
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Cognitive Bias in the Judgment of Business Valuations and Valuators
Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.
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2014
LIBC PUBLIEKSDAG 'HUMAN POTENTIAL; OPTIMALISEER JEZELF, TRAIN JE HERSENEN' (in Dutch)
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Algorithms for the description of molecular sequences
Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Assemblage and functioning of bacterial communities in soil and rhizosphere
Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Visual Relation extraction Based on Deep Cross-media Transfer Network
Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Machine learning-based NO2 estimation from seagoing ships using TROPOMI/S5P satellite data
The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.
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Functionalized two-dimensional membranes and materials for solar-to-fuel devices: a multiscale computational approach
In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Modeling vascular disease using self-assembling human induced pluripotent stem cell derivatives in 3D vessels-on-chip
Promotie
- Presenting Medieval Research at International Conferences (5 ECTS)
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Andrea Evers over placebo-effect en conditionering
Het eerste wereldwijde congres over placebostudies van 2-4 april moest uitwijken naar de Stadsgehoorzaal om de deelnemers uit 20 landen te ontvangen. Ook de Nederlandse media lieten zich niet onbetuigd. Bekijk een selectie uit het nieuws met Andrea Evers over placebo's en conditionering.
- International Symposium: Good Governance (1/2 ECTS)
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Rechtenfaculteit Leiden viert 5 jaar Frontiers of Children’s Rights Summer School
Op woensdag 5 juli 2017 organiseerden de Afdeling Jeugdrecht en het Grotius Centre for International Legal Studies van de faculteit der Rechtsgeleerdheid een feestelijke borrel ter ere van het 5-jarig bestaan van de ‘Frontiers of Children’s Rights’ summer school. De summer school heeft sinds de oprichting…
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characterization and clinical implications of specific anatomical features in human coronary arteries
Promotie
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Freya Baetens gastprofessor aan de National University Singapore
Freya Baetens is momenteel gastprofessor aan de National University Singapore (NUS). NUS begon als een medische faculteit in 1905, opgericht door een vastbesloten groep van zakenlui onder leiding van Tan Jiak Kim, om aan de noden van de lokale bevolking tegemoet te komen. Vandaag is NUS het academische…
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Using human pluripotent stem cell-derived cardiomyocytes to understand genetic variant pathogenicity in the ion channelopathy LQT2
Promotie
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therapy coming of age: Mechanistic insight and rAAV assays on mouse & human retinal organoid models
Promotie
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Leiden Consortium on Individual Development (L-CID)
Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?
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creatIef, Creatiever, creaTiefst? Onderzoek naar het belang en de werking van creativiteitstraining bij Bachelor ICT-studenten
This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.
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Interactions of nutrients and pesticides and their effects on aquatic macrofauna
Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?
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Adding fuel to the conflict : how gas reserves complicate the Cyprus question
In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Global distribution patterns of distinct mycorrhizal types and ecological drivers of these patterns
What are the global relationships between environmental conditions and abundance of distinct types of mycorrhizal fungi in soil and plant roots?
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Unfolding the principles of genome folding and dynamics in bacteria
Remus Dame
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Species Literacy: The perception and cultural portrayal of animals
In his dissertation Michiel Hooykaas outlines the results of six empirical research projects focused at biodiversity awareness in the Netherlands, specifically people’s knowledge about animals.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska