The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Irene Morfini verdedigde haar proefschrift op 21 february 2019

In de specialisatie Ancient History (research) van de Universiteit Leiden bestudeer je de geschiedenis van de Griekse en Romeinse periode, in het bijzonder de mentaliteit en de sociale en economische geschiedenis in de periode van 400 voor Chr. tot 400 na Chr.

De master Ancient History van de Universiteit Leiden biedt een compleet en breed overzicht van de geschiedenis van de Griekse en Romeinse periode, met speciale aandacht voor de denkwijze en de sociaal-economische geschiedenis in de periode van 400 v.Chr – 400 na Chr.

Hoe beinvloed de structuur van één enkel gen de activiteit van genen die gevoelig zijn voor hormonen?

De master Classics and Ancient Civilizations van de Universiteit Leiden is van hoog niveau. De opleiding gaat diep in op een van de belangrijkste domeinen van het intellectuele leven: de talen, geschiedenis, culturen en filosofie van de oude beschavingen.

Dit project beoogt de multidirectionele effecten van gedwongen en vrijwillige vormen van migratie in het oude Nabije Oosten te onderzoeken.

De onderzoeksmaster Classics and Ancient Civilizations (research) van de Universiteit Leiden beslaat het volledige spectrum van het huidig onderzoek naar de beschavingen van de Grieken en de Romeinen, Egypte en het Oude Nabije-Oosten.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019

Promotor: Prof.dr. G.P. van Wezel

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Radboud Ancient and Medieval Studies organiseert ook dit jaar een lezingenreeks. Het programma voor het eerste semester is hieronder te vinden.

Drie alumni van onze MA Ancient History vertellen hoe zij in coronatijd een baan vonden na hun afstuderen. Gabriël hing tijdens het gesprek een enorm bord met post-its als geheugensteuntje achter zijn laptop, Molly was blij dat de leden van de solllicitatiecommissie een ‘name tag’ op het scherm hadden…

De leerstoelgroep Oude en Middeleeuwse Geschiedenis aan de Radboud Universiteit organiseert een lezingenreeks tussen februari en juni 2024. De exacte data en tijden staan in het onderstaande programma.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Migration and Mobility in the Early Roman Empire by Luuk de Ligt and Laurens E. Tacoma (Eds.)

To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink. Co-promotor: C.P. Bagowski

Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).