Bikes are one of the most sustainable ways of travel which use should be promoted by the University.

Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?

We are delighted to welcome Dr. Barrie Sander as Visiting Fellow of The Hague Program for Cyber Norms at Leiden University’s Institute of Security and Global Affairs from 27 September till 4 October 2017.

In this article, the authors explore how international criminal law is moving into a ‘post-critical’ phase and examine its potential for emancipatory reform.

The European Commission adopted a proposal regarding common rules promoting the right to repair for consumers.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

On 27 June 2019, Barry Bussey defended his thesis 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. The doctoral research was supervised by Prof. dr. P.B. Cliteur.

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…

By analysing neglected (continental) spy centres and integrating these groups of female intelligencers into the traditional, male-orientated historical narratives, this project will proceed towards a gendered history of early modern espionage.

This edited publication aims at reflecting on the future of discussions on the applicability of international law to States’ use of ICTs in the context of highly politicised discussions at the multilateral level and offering practical suggestions for the European Union to pursue its objectives in this…

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How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

PhD defence

PhD defence

PhD defence

Efficient gene-targeting during meiosis

Wanted for the Re-pair study!

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

PhD defence

PhD defence

PhD defence

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Around the world, there is a growing movement to decolonise university curricula, with both students and educators seeking to disrupt existing epistemic hierarchies within higher education. This research project aims to unravel what decolonising means in general and what it means for the International…

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…

A team of researchers has managed to recreate the most natural skin cream in existence. Using the DUBBLE beamline (Dutch Belgian Beamline) at the European Synchrotron Radiation produced on the basis of the information identified, has the same properties as vernix caseosa. This cream may have a therapeutic…

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…