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The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…

This year’s edition of PRINS, the International Studies’ consultancy course, proved to be an inspiring event for most of its participants. Students, coaches and representatives of organisations are looking back on this rollercoaster of a course and reflect on why the PRINS experience is so special.

On the 31 March 2022 Mr. Taufiq Hanafi successfully defended a doctoral thesis and graduated.

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

PhD defence

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

We are aiming to develop novel technologies to allow better sample preparation or coupling of analytical methods to (i) analyse ultra small samples, (ii) to analyse more metabolites in a quantitative manner and/or (iii) increase the sample throughput.

Can cyclic peptides provide a new generation of antibiotics?

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Is is possible to better predict the validity of drug candidates?

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

His PhD research project - entitled Charlemagne's Workshops - is an ongoing investigation into the role of copper-alloy craft production in the early medieval economy of North-west Europe. The geographic limits of this research have up until now centred on the Netherlands (Frisia Magna in medieval times)…

Jos Wienen, the mayor of Haarlem is in hiding because of threats from an unknown source. Researcher Ruth Prins talked about this in the tv-programme ‘Na het nieuws’.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Students in the third year of the BA International Studies programme follow the Practicing International Studies (PRINS) consultancy course. They conduct a project put forward by real clients and then present them with their research results. PRINS is so successful that it has now been running for 10…

The Prins Bernhard Cultuurfonds Award this year goes to musician, conductor and composer Reinbert de Leeuw, because of his great merit for contemporary music within The Netherlands and abroad.

The World Food Programme, Philips, the European Space Agency. An overwhelming list of organisations that Sarita Koendjbiharie, as founder of the PRINS consultancy programme of International Studies, has managed to recruit. ‘We keep reaching new highs and insights together with our students and organ…

Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

In the article, Ruth Prins gives her opinion on the possible consequences chosen mayors might have for the police.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

The university’s largest consultancy programme, International Studies’ PRINS, has been connecting international employers with humanities students for six years. Founder Sarita Koendjbiharie: ‘Students of International Studies offer the holistic view that complex social issues need.’