In this thesis we present several methods to automate tomographic reconstruction algorithms and several novel tomographic reconstruction algorithms with the focus on being easily applicable and efficient to use.

Efficient gene-targeting during meiosis

Born in Europe roughly 100 years ago, quantum physics brought forth a veritable technological revolution through semiconductors, lasers, fibre optics, and many other technologies that are today ubiquitous in our lives. Now, during the second quantum revolution, Europe can take the lead once more in…

In what way can the chemical properties of cobalt porphyrines be adjusted to optimize their selectivity and activity when using them for the electrochemical conversion of CO2 to methane and methanol?

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?

What are the environmental trade-offs for SMEs considering moving from monoculture aquaculture practice towards IMTA? What are the environmental trade-offs comparing IMTA species with their conventional monoculture alternatives?

Young children, adolescents and students may experience learning difficulties as a result of lack of sleep. Dr Kristiaan van der Heijden investigates sleep problems and solutions for various age groups.

Over time, the temperature in all buildings will be regulated in a sustainable manner. In this way, using gas will not be necessary anymore.

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

On 24 November 2015, Prof. Carsten Stahn participated as external expert in a special plenary session of the Assembly of States Parties on the efficiency and effectiveness of Court proceedings, chaired by the co-chairs of the Study Group on Governance of the Assembly.

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Schneider

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

Promotor: A. Kros

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

To develop good cancer treatments, we need to know much more about how malignant tumour cells develop. Professor Ewa Snaar-Jagalska looks at not just the effect of medication on isolated cells but also the behaviour of cancer cells in their tissue environment. Inaugural lecture on 11 December.

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

The recently promoted Hao Wang from the Leiden Institute of Advanced Computer Science teaches computer programmes how to solve real-world problems. His goal is to make the process of problem-solving more efficient. On 1 November, he obtained his doctorate with the predicate cum laude. ‘I hope to solve…

Sharing scientific data, transferring money, or sending other sensitive information online: with cryptography, applications make sure your data does not fall into the wrong hands. Mathematician Thomas Attema (CWI/TNO/Leiden University) helps with this. For his PhD research, he developed a new technique…

On 28 September the famous chemists Carolyn Bertozzi visited Leiden University to speak at the LED3 seminar. Just one week later, she was announced winner the 2022 Nobel Prize in Chemistry. Leiden chemists Sebastian Pomplun and Hermen Overkleeft are fan: ‘We are extremely honoured to have hosted this…

Scientists have long been puzzled why it is easier to produce hydrogen from water in an acidic environment than in an alkaline environment. Marc Koper comes with an explanation: the reason is the electric field at the surface of the catalyst, which is larger in an alkaline environment, as he writes…

More efficient use of phosphorus fertilisers would make it possible to meet food demand in 2050, without using more of the world’s land for agriculture. This is what environmental scientists José Mogollón and colleagues have discovered by working out various future scenarios for food production and…

Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.

It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…

Research of the Leiden Institute of Chemistry into the development of a sustainable fuel cell has accidentally resulted in an exceptionally efficient catalyst for the production of hydrogen peroxide. The catalyst, discovered by Dennis Hetterscheid and PhD candidate Michiel Langerman, may lead to a more…

As of 1 October Rob van Nieuwpoort is the new professor of Efficient Computing and eScience at the Leiden Institute of Advanced Computer Science (LIACS). Van Nieuwpoort brings with him a wealth of expertise: he is an expert in eScience, high performace computing and advanced algorithms.

The STW project Energy Efficient Computer-Brain Interaction (principal investigator for LIACS: dr. T.P. Stefanov) has been granted. Funding for LIACS: 1 PhD student + travel/equipment budget, project duration: 4 years.

Why is the swimming efficiency of the European eel higher than predicted?

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

In mid-March 2020, the global coronavirus outbreak changed everything in the Netherlands. Staying at home as much as possible and the 1.5 metre rule became the standard. One year on, we reflect on the past year with four Leiden Law School ‘insiders’. What kind of year did they have? And what are their…

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

On Tuesday 10 March 2015 - 10h Ernst Worrell, professor at the University of Utrecht with a chair on

Many pharmaceutical companies no longer have their own lab and are working more closely with universities and start-ups of scientists. Professor of Science-Based Business Simcha Jong is researching how scientific ideas result in new drugs, including at the Leiden Bio Science Park (LBSP).

A tenacious postdoc researcher persuaded Professor Marc Koper to research the oxygen reduction reaction. In Koper's eyes, there was little of interest there. But they promptly discovered a whole new way to improve fuel cells on hydrogen and oxygen. Their article appeared in Nature Catalysis on 07 Ju…

Bjørn Peare Bartholdy is Archaeology’s representative in the Open Science Community Leiden (OSCL) . We spoke with him about the value of Open Science and how to make a good start. ‘Open Science is headed to be a regular way of academic work.’ So better to jump on the Open Science bandwagon early on.

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese

How might we include circularity into the models often used in IPCC reporting (in technical language, how can IAMs, dMFA models and CGE models be integrated?) What are possible futures for global resource use and what are the consequences for greenhouse gas emissions in these scenarios?

Physicist Remko Fermin from Leiden University was awarded a Rubicon grant from NWO. He will use it to study superconducting diodes that could contribute to reducing the CO2 emission of data centres.

Lecture

Integrating life cycle assessment (LCA) with life cycle costing (LCC) offers the opportunity to simultaneously analyze the environmental and economic aspects of product alternatives, for the integration of which a unified computational has been proposed by Heijungs et al. (2013) [1]. The project aims…

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

Juurlink