Promotores: K.J. Batenburg, B. Koren

This dissertation presents new cryptographic protocols, which can be divided into two families.

The HOPES study is one of the largest investigations of this kind to date! By studying existing brain scans and data collected form over 4,000 14-25 year olds, the project team hopes to identify specific changes in the brain that make young people vulnerable to suicidal thoughts and behaviours.

Promotor: M. de Jong, Co-Promotor: Samtleben

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Promotor: M.A.G.J. Orrit

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.

Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel

Promotor: T.H. Oosterkamp

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

Sarah Giest and Annemarie Samuels, both Assistant Professors at Leiden University, researched the quality and coverage of the data being collected for policiymakers to be used, specifically pertaining to minority groups.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

This article provides an in‐depth assessment of lone actor terrorists’ attack planning and preparation.

It is with great pleasure that we present to you the second volume of Inter-Section, published in 2017.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Studying the underlying principles of the nature of language.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

The Faculty of Humanities

Cognitive psychology is the study of cognitive functions such as attention, memory, consciousness, emotion, language and action control. The goal is to understand the complex relationships between brain, mind and behavior.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

High resolution altitude data created by airborne LiDAR allow the investigation of large areas and often inaccessible tracts of land and has the potential to reveal undiscovered archaeological heritage.

The mechanism of the electrochemical reduction of dioxygen by a mononuclear pyridylalkylamine copper complex was investigated (see picture). It was shown that in neutral aqueous solution dioxygen undergoes stepwise reduction, wherein hydrogen peroxide plays a key role. The rate constants determined…

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: V. Vitelli, Co-promotor: J. Paulose

Our cantilevers have a low intrinsic damping rate: this enables us to measure with low noise, since damping is proportionate to noise. However, when the magnet is close to the surface of a sample we want to study, we measure a much higher effective damping rate. This is caused by magnetic interaction…

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

This thesis focuses on protoplanetary disks: flattened structures of gas and dust around young stars in which planets are expected to form and grow.

In the contemporary myriad of definitions and approaches of landscape, the starting points and limits of the concept of landscape biography are being explored, but also tested in this thesis. What exactly is a landscape biography? What does it constitute of? Is landscape biography just a narration of…

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

This research note argues that the “lone wolf” typology should be fundamentally reconsidered.

Promotor: Prof.dr. C.W.J. Beenakker

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.