Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

What are the principles of genome folding and dynamics in bacteria?

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This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with the University of Pretoria.

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science and Sichuan University’s College of Mathematics.

Promotor: B. van de Water

Supervisor: P.J.J. Hooykaas

List of Support Departments at LION and the Faculty of Science

Promotor: Roeland M.H. Merks

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In the Psychology Lab on Wheels, we conduct innovative research together with citizens. We drive our mobile lab to people all over the country helping to bridge the gap between science and society.

Physics and Engineering Approaches to Biomedicine and Pharmacology

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

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Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

PhD defence

PhD defence

PhD defence

The Green algae Chara as model system for intra and inter cellular transport processes.

As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

PhD defence

PhD defence

PhD defence

PhD defence

In this project, M. Riep studies the complexity of historical events related to the Arab conquest of the region along the upper course of the Syr Darya in Central Asia and especially of the micro oases of Shash and Ferghana. This project focusses on mobility, action and dynamics and will place the Arab…

This is an Erasmus+ International Credit Mobility project of Leiden Law School with the University of Rwanda.

This is an Erasmus+ International Credit Mobility project of Leiden Law School with the University of Tirana.

This is an Erasmus+ International Credit Mobility project of Leiden Law School with the University of Dar es Salaam.

This is an Erasmus+ International Credit Mobility project of Leiden Law School with three universities in Kenya.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

GitLab is a single application for the entire software development lifecycle. We use the Leiden University gitlab services

Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…