It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

This project combines and reconsiders all the available evidence of the Scheurrak SO1, and use new archival databases and modern archaeological techniques to shed new light on the material culture of the Baltic grain trade and the Holland shipbuilding industry at the turn of the sixteenth century.

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

A comprehensive analysis of Nietzsche's conception of conflict and the way in which relations of struggle condition the organisation of complex systems (with a specific focus on the human psyche and the body politic).

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Promotor: Prof.dr. G.J. Kroes

This dissertation focuses on the question how text and paratext contribute to the way that text in a network-like environment is clearly bordered and at the same time can easily be linked to other texts.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

A lot of our research is performed at temperatures close to absolute zero, among other reasons because this increases the sensitivity of the measurements. 

What was the practice of keeping the Necropolis Journal?

This volume provides one of the most comprehensive overviews of the archaeology of a single Caribbean island yet published. Drawing together scholars from the Caribbean, north America and Europe, all working from a range of disciplines within the broader scope of archaeology, and drawing upon recent…

Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

This dissertations studies state-society relations in 1930s Turkey, focusing on the anti-veiling campaigns in the mid-1930s and aiming to understand the ways in which the Kemalist policies were received, interpreted, negotiated, compromised and/or resisted by various actors in the provinces.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.

How do crises produce changes in specific European Union foreign policy areas, and how should we conceptualise these policy changes?

Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.

Matthias Haentjens, Jouke Tegelaar and Dorine Verheij have recently published the chapter Financial Market Regulation and Supervision in the new volume of the prestigious The Law of the European Union (previously Kapteyn and VerLoren van Themaat).

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink

Within the Chinese medicine, more than 80% of the constituents of the preparations are derived from plants. Like any other organism, plants are constantly interacting with their changing and often harsh environment during the various phases of their life cycle.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

Are you an international student looking for a non-degree programme at Leiden University? Or are you an international staff member, interested in an exchange with Leiden University?

Dialogue is a multi-dimensional communication mechanism whose processes can only be examined by means of an interdisciplinary approach.

This book focuses on policing in city-regions in Europe bringing together experts from across the continent to develop a sociology of urban policing and a unique methodology for comparing different metropolises in the same country.

This study examines the mutual intelligibility between all 225 pairs of 15 Chinese dialects, in two main branches, i.e., six Mandarin dialects and nine non-Mandarin (Southern) dialects.

To what extent is creative ownership in contemporary (graphic) design practices changing now that we are co-creating with machines? And can machines have copyrights, too?

The main objectives of this project are to measure and explain government-opposition distinctiveness and to study its consequences for democratic legitimacy and vote choice.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

The global agri-food system plays a critical role in food security and environmental issues.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

This volume challenges the idea that the development of ‘democracy’ is a story of rise and progress at all. It is rather a story of continuous but never completely satisfying attempts of interpreting the rule of the people.

Source: J Cheminform, Volume 7, Issue 1 (2015)

A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

We explore the particle physics and quantum world at the time of the big bang.

This dissertation looks into the role of discretion granted by EU directives (Article 288 Treaty on Functioning of the European Union) in legislative decision-making and national transposition processes of these directives.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

The public sector is increasingly a multi-level system, with interactions between public and private actors on the national, sub-national (provinces, regions) and international level and various public, semi-public and private organisations that perform public tasks. In this minor students pay attention…