2,647 search results for “cell mobility” in the Public website
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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Nationalism, Ethnic Conflict and Development (MSc)
Study why and how, in countries around the world, people mobilize around ethnic, racial, religious and social identities, and explore the role of political institutions in mitigating conflicts that arise from such mobilization.
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Dutch Centre for Travel Writing Studies
The Dutch Center for Travel Writing Studies s a scientific center that develops and coordinates initiatives to promote research into travel writing. It actively seeks contact with external (scientific and social) partners to collaborate on issues surrounding cultural / national identity, cultural contact…
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Tenosynovial Giant Cell Tumours
PhD defence
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Key publications
Key publications of the Cardiovascular Pharmacology group
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Light-activatable ruthenium-based anticancer prodrugs
Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?
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Indonesia
This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Medicine with University of Indonesia, Faculty of Medicine, and Universitas Katolik Indonesia Atma Jaya in Indonesia.
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Indonesia
This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Law with Gadjah Mada University.
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United States
This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with University of California.
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Morocco
This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Humanities with Mohammed VI Polytechnic University.
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Lebanon
This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Law with Holy Spirit University of Kaslik.
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Ukraine
This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with National University of Kyiv, National University of Lviv, Odessa National Maritime University, Odessa National University, and V. N. Karazin Kharkiv National University in Ukraine.
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Israel
This is an Erasmus+ International Credit Mobility project of Leiden University (university wide) with The Hebrew University of Jerusalem.
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.
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Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS
Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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Cryo-EM of cholera infection
The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?
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Hybrid vesicles
Synthetic cells, also known as artificial cells or protocells, have wide ranging applications from drug delivery vectors to cell models. In biotechnology they can function as micro- or nanoreactors with possible applications in biocatalysis and photocatalysis. Phospholipids are by far the most commonly…
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Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
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TranSensusLCA
The research aims at achieving a European consensus on a harmonized LCA approach/framework to be applied in E-mobility sector. The research will focus on needs and gaps in current LCA practices in E-mobility and try to provide solutions for them based on the rich knowledge and experience represented…
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Resetting the immune system to cure diabetes and rheumatism
In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.
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SiTaSol
What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?
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Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.
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New imaging technology to assess early drug success
Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…
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About the program
In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.
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Discovery of metastasis promoting candidate drug targets
Discovery of metastasis promoting candidate drug targets
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Software
Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements
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Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
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Unravelling cell fate decisions through single cell methods and mathematical models
PhD defence
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Theory
Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…
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Image-based Computational Biology
In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…
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Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Thomas Schmidt Lab - Single Molecule Microscopy
Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Grant: Dr. Amanda Foks receives a prestigious Junior Postdoc fellowship from the Dr. E. Dekker stipendium awarded by the Dutch Heart Foundation
Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.
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Colombia
This is an Erasmus+ International Credit Mobility project of the Faculty of Science with three universities in Colombia.