Dario Fazzi

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics

On 15 February 2024, Alexandros Sarris defended the thesis 'International Law and Governance of the Arctic in an Era of Climate Change'. The doctoral research was supervised by Nico Schrijver and Freya Baetens.

A lecturer winning a prize, an expert appearing in the media or a professor giving their inaugural speech: these are faces we often see. But we rarely see the staff who work behind the scenes to make their work possible. They are now featured in the photo exhibition ‘The forces behind the faces’.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

What is better for waste recycling: a plastic, paper or ceramic cup? A bio-based or fossil-based coating? Waste sorting at the source or at a recycling facility? Ask ten experts and you will get ten different opinions. We can all agree on one thing: doing nothing is not an option. Thus, Leiden University…

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

How can collaborative participatory action research by student-teachers and their students enhance student participation, improve educational practices, and generate knowledge about these practices that can be used for improving teacher education as well?

Plants could be regarded as small chemical factories, which produce chemical substances via photosynthesis. If we can imitate photosynthesis in an artificial system, we can make clean fuels and materials out of sunlight and CO2. Huub de Groot is very close to designing a system of this kind.

AI-tools are introduced within our infrastructure, work, communication, interpersonal relations, economy, democracy, health, science etcetera, to overcome limitations and/or increase efficiency, speed, reliability, convenience. Given the impacts across society, AI requires broad action and reflection…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

The renovation of the Herta Mohr building (formerly known as Cluster Zuid) is completed. It is the third project in the redevelopment of the Humanities Campus. With the renewal of these buildings, the university ensures a sustainable campus with modern facilities. The university wants to create an attractive…

Leiden University’s Master of Laws in Advanced Studies in Law and Finance (L.L.M.) examines the complex, international and multidisciplinary area of law and finance: markets, regulation and a sustainable society.

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

Drug development is a complex process in which many parties work together. Every day, the researchers at LACDR devote their energies to developing drugs that are new, better, more efficient and easier to produce. And thus to the millions of patients who know all too well why this research in Leiden…

Many students have difficulties to read and give meaning to algebraic formulas. In this study it is explored whether graphing formulas with pen and paper will improve students’ability to reason with algebraic formulas.

Read more about the International Network Open Science & Scholarship Communities in our Vision and Mission statements.

Research at the MCBIM group is comprised of the following research themes:

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

The

The programme consists out of three phases: the orientations phase, de pre-PhD phase, and the PhD phase. Each phase has its own characteristics and goals, that are explained below.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

How to improve the method in quantifying the combined effects of metal-based chemicals?

What are the various forms of inter-organizational collaboration in the public safety sector? How are different forms of inter-organizational collaborative arrangements related? What is the relationship between inter-organizational collaboration and innovation in the public safety sector?

On 18 September 2019, Huw Llewellyn defended his thesis 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. The doctoral research was supervised by Prof. N.M. Blokker and Prof. L.J. van den Herik.

April 2021 saw the publication of the book ‘Cross-Border Protocols in Insolvencies of Multinational Enterprise Groups’. This book was published by Edward Elgar Publishing. It is written by Ilya Kokorin and Bob Wessels. The book serves as a comprehensive introduction to insolvency protocols and focuses…

Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.

We examine how soil inoculation influences aboveground organisms (i) directly, and indirectly via (ii) its effects on plant chemistry or volatile emission, or via (iii) mediating the effects of belowground pathogens on aboveground organisms via the shared plant.

Advancing the understanding of the interaction of light and matter on the single-quantum level is important for near-future quantum technologies but also to answer fundamental questions.

How are the building blocks of life formed?

Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

Water, Urbanism, and Sustainability in Roman Ostia

Review of new technical decisionsupport systems in the environmental field, and application in water management decission processes.

NeuroSoC concentrates on multiprocessor systems on chip with in-memory neural processing units.

The research profile ‘Asian Modernities and Traditions’ (AMT) aims to raise the strength and visibility of research, teaching and dissemination on Asian studies at Leiden University.

1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

Key publications of the Medical Systems Biophysics and Bioengineeringgroup (Mashaghi Lab)

The fourth volume of Ex Novo has the pleasure to host Heleen van Londen, Marjo J. Schlaman, and Andrea Travaglia as guest editors of the special issue titled The Natural and The Cultural. Integrating Approaches in Landscape Heritage Management. This timely collection of peer-reviewed papers and short…

An overview of research themes and projects at ABS.

Shah recently wrote an op-ed for the Commentaries series of the Istituto Affari Internazionali in Rome, which has been published online. The piece is on India’s performance and priorities regarding the UN sustainable development goals (SDGs) and collaboration with the EU.

‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…

Legal proceedings are often time-consuming, costly and stressful. Accessible out-of-court dispute resolution can sometimes offer a good alternative, but having access to reliable and efficient judicial proceedings remains equally important.