Promotor: Prof.dr. T.H.W. Bäck

Toward optimal measurement and greater understanding of youth cognition in school refusal and cognitive behavioural therapy outcome

The Leiden Institute of Advanced Computer Science (LIACS) of Leiden University proudly establishes the Blaise Pascal chair. The chair applies for one year and is meant to strengthen the cooperation of the Leiden computer science research with foreign institutes.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.

Promotor: M.A.G.J. Orrit

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

This article researches the public perception of terrorist attacks by measuring the importance the public assigns to attributes of terrorist attacks.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

To contribute to the body of knowledge aiming at a better coverage of ecosystem service assessment in LCA studies, this thesis dives into the challenges of incorporating existing ecosystem service methods within the impact assessment phase of the conventional LCA framework.

On 21 February 2019, Ruben Zandvliet defended his thesis 'Trade, Investment and Labour: Interactions in International Law'. The doctoral research was supervised by Prof. dr. N.J. Schrijver.

Promotor: M. Ubbink, Co-promotor: G. Siegal

This thesis provides an overview of the development of the Pair Configuration to Molecular Activity Coefficient (PAC-MAC) model.

Today, everybody and everything produces data. People produce large amounts of data in social networks and in commercial transactions. Medical, corporate, and government databases continue to grow. Sensors continue to get cheaper and are increasingly connected, creating an Internet of Things, and generating…

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Promotores: J. Jonkers, K.E. de Visser

Promotores: J.C. van Houwelingen, S.A. van de Geer

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

On the 23d of May, Sanne Rotmeijer successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Sanne on this achievement!

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When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotor: Huub J.M. de Groot, Co-promotor: Francesco Buda

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

What kind of attentional focus can enhance learning and performance for musicians?

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

On 11 November 2021, Mariana Gkliati defended the thesis 'Systemic Accountability of the European Border and Coast Guard'. The doctoral research was supervised by Prof. P. Rodrigues and Prof. L. Besselink (UvA).

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

The research connected to this topic is related to E-health.

What is the role of the noradrenergic system in human cognition?

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.

Atherosclerosis, in particular rupture of atherosclerotic plaques, is the underlying cause of most heart attacks or strokes and is the leading cause of death worldwide.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.