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The PML specialisation prepares you with knowledge and understanding of the key concepts and theories of management, leadership, decision-making and policy implementation in national and international government organizations.

LLInC supports innovative and high-quality education, within Leiden University and in partnership with academic and social organisations.

On Tuesday 3 September 2024 Straton Papagianneas successfully defended a doctoral thesis and graduated.

The MSc program Evolutionary Biology focuses on important factors for the evolution of organisms. It prepares you for a research careers at universities, research institutes, or biotechnology sector. It’s also possible to combine training in biological research with training in communication, education…

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?

What is the role of cell wall-deficiency in the persistence of tuberculosis?

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

Promotores: J. Kok, M. Chaudron (Chalmers University)

Dario Fazzi

How to strike a balance between the sometimes conflicting stakes of individual, public and private data-producers and data-processors?

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Promotor: Prof.dr. H.J.A. Rottgering, Co-promotor: David Sobral

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

Source: PLoS ONE, Volume 10, Issue 3 (2015)

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

M. Danhof, Co-promotor: O.E. Della Pasqua

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Leiden University and the Ministry of Infrastructure and Water Management are involved in a collaboration in the form of a research project titled 'Data-Driven Risk Assessment in Infrastructure Networks'.

This study examines the mutual intelligibility between all 225 pairs of 15 Chinese dialects, in two main branches, i.e., six Mandarin dialects and nine non-Mandarin (Southern) dialects.

Our previous meta-analysis (Swart et al., 2019) had shown that feedback targeting text comprehension given when students perform a reading task positively influences learning from text. So far, differences in the effects of feedback were explained by design features, such as the timing and richness…

A research into for whom, when and why the Cool Little Kids intervention works.

PhD at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

What tools can be applied to measure the output, outcome and impact of science communication efficiently and effectively?

Key publications of the Barz Lab

On Thursday 11 May 2017, Qiang Yu defended his doctoral thesis ‘Market Power and Competition Law in the Software Industry’. The supervisors of the research are Professor T.R. Ottervanger and Professor S.C.G. Van den Bogaert. A brief summary of his thesis is provided below.

What are the determinants of the willingness to administer rewards for cooperation and punishments for non-cooperation, and how do they influence people’s sanctioning behavior?

How can Critical Raw Material policies/strategies be enhanced in the EU context?

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Artificial photosynthesis aims to produce fuels from solar energy using chemical processes. In semi-artificial photosynthesis, a hybrid approach is taken using both chemical and biotechnology approaches. We aim to develop hybrid systems between light-harvesting nanoparticles and redox-enzymes (oxidoreductases)…

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.