2,434 search results for “tools” in the Public website
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Molecular mechanisms of adverse outcome and translational biomarkers
Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…
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Printeger – Promoting integrity as an integral dimension of excellence in research
The mission of Printeger is to enhance research integrity by promoting a research culture in which integrity is part and parcel of what it means to do excellent research, and not just an external and restrictive control system.
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers
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Graphene at fluidic interfaces
In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…
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MICA – Material Intelligence Capacity Analysis
Can we develop a platform for raw materials intelligence?
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Techno-typological variability of the late Middle Paleolithic in the southern Balkans
Middle Paleolithic stone tool technology is one of the major sources of information about Neandertal behavior and adaptations. The Balkan Middle Paleolithic often remains outside of the major debates and interpretations of Neandertal behavior.
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UBC Europe – University-Business Cooperation in Europe
To goal of this project is to get a deeper, more comprehensive and up to date understanding of the state of University-Business Cooperations (UBC) in Europe, from the perspective of both the Higher Education Institutions and the business sector.
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Focusdata: Foreign Policy through Language and Sentiment
In this article Fisher, Klein & Codjo introduce the FOCUSdate Project and they show how the sentiment data provide unique abilities to analyze Russia's and Iran's reactions to US policies and events and NGO human rights campaigns.
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Fostering Curiosity Through Video Games
This thesis manuscript explores the use of video games as tools for conceptual exploration and academic research.
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Aria of the Dutch North Sea
Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn
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U-Multirank – Ranking of Higher-Education Institutions
U-Multirank is an alternative approach to international ranking of higher education institutions (HEIs) worldwide. This analytical tool is user-driven and multi-dimensional by design. The current version (2016/2017) includes 1 600 HEIs. The ranking system compares the relative performance of HEIs (mostly…
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Hydrocarbons in interstellar ice analogues: UV-vis spectroscopy and VUV photochemistry
Promotor: Prof.dr. H.L.V. Linnartz
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DH Pilot Projects Symposium and Digital Skills Workshops – Winter Weeks
We hold the annual Digital Humanities Pilot Project Symposium and Digital Skills Winter Workshop Week in the last week of January. It is open to all LU staff and PhD/MA students.
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Research
On these pages you will find information on the research that is being conducted at each of the participating universities as well as the funding programme set up by the Research School.
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Career preparation
Leiden University offers you several services related to career orientation and job application skills.
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Career preparation
Leiden University offers you several services related to career orientation and job application skills.
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Research groups
The research at The Metabolomics & Analytics Centre is centered around developing innovating analytical methods to enable metabolomics-driven systems biology in personalized health strategies.
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Artefact biographies from Mesolithic and Neolithic Europe and beyond
Papers in honour of Professor Annelou van Gijn
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The domestic implements of the Single Grave Culture: the case of the Noord-Holland province
The use-wear analysis of domestic implements provided new insights of the Single Grave Culture population in the Netherlands.
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FitDis!
This 1.0 version of FitDis! is an archive containing the tool, a quick manual and a test dataset. The FitDis_M.zip package contains the sourcecode Matlab M-files.
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Equipment
We offer a modest collection of tools and devices for student to borrow. Typically they are items that students use for their projects.
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Energy Use
For Leiden University’s operations, sustainability is an important topic, especially looking at the CO2-footprint, renewable energy and the greening of buildings.
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Image analysis & storage
Obtaining imaging data is nowadays only the start of your project. Once the data has been acquired there are many things that still need to be done.
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Manioc roots
Prehistory of Amazonia seen from the kitchen
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Capillary Electrophoresis-Mass Spectrometry based Metabolomics Approaches for Volume-restricted Applications
Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…
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Dutch Politics (MSc)
Combine the analytical tools of the Political Science discipline with an in-depth study of current politics in the Netherlands.
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Starchy foodways: surveying indigenous botanical foods during the advent of European encounters in the northern and circum-Caribbean
How do the starchy botanical foodways reflect upon previous archaeological understandings in the northern and circum-Caribbean?
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Into the cold: The adaptive role of pyrotechnology among the earliest modern humans in Europe, ca. 45,000–20,000 years ago
The routine assumption that Upper Palaeolithic early modern humans in Europe were regular fire users who produced fire at will has never been tested against the archaeological record. Utilizing literature, database and microwear analytical approaches, this project seeks to establish the role and forms…
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Detecting cross-linguistic syntactic differences automatically
So far it has been impossible to compare large sets of syntactic constructions in large sets of languages systematically and automatically. The online availability of parallel text corpora and software tools to align, enrich, search and analyse them has the potential to make automatic massive systematic…
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A culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.
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GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
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Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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First Steps for Teachers and Facilities
Getting started with active learning & teaching can be as simple as assessing on what is already accomplished. Here are some practical courses of action to begin experimenting with active learning, whether you are a teacher or responsible for the spaces.
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Development of Cost efficient Advanced DNA-based methods for specific Traceability issues and High Level On-site applications
Schneider
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Diversifying Ancient History
The project ‘Diversifying Ancient History’, sponsored by the JEDI Fund from the Faculty of Humanities, aims to thoroughly revise the first-year curriculum of Ancient History. Through these innovations, the course will cater the needs of the present generation.
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Software and data for circular economy assessment
This thesis investigates how the assessment of circular economy (CE) at the macro-economic level can be facilitated and promoted.
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Cryptography from quantum uncertainty in the presence of quantum side information
Promotor: Ronald Cramer, Co-promotor: Serge Fehr
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Measuring science communication impact
What tools can be applied to measure the output, outcome and impact of science communication efficiently and effectively?
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Technological innovation in neuropsychology
Technological advances, such as virtual reality, augmented reality and online assessment platforms are rapidly improving. These tools could potentially contribute to neuropsychological assessment that is more efficient and of higher quality.
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On the nature of preverbal Focus in Greek. A theoretical and experimental approach
This thesis aims at contributing to our understanding of the semantic and prosodic properties of object foci in Greek, employing theoretical and experimental tools.
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Unlocking Nature’s Pharmacy from Bogland Species
Development of Natural Resource for New Medicines
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Burning the land
A global synthesis of the extent, diversity and patterns in off-site fire use by historically documented and current hunter-gatherers with the remit of this study in the deeper past.