1,438 search results for “elderly patients” in the Public website
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Innovation in Health Strategy and Quality of Care
The focus of health care is rapidly changing. The need for maximum gains with minimal input requires tailored health care strategies and an ever more explicit evaluation of health benefits for the patient.
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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Statistical learning for complex data to enable precision medicine strategies
Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.
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Translational Neuroscience
Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
- Medicine (BSc)
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OPENup: Optimizing exposure therapy for Posttraumatic Stress disorder
Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Healthy ageing? Shift the focus from the individual to the population
David van Bodegom, Professor of Vitality in an Ageing Population, will give his inaugural lecture on 11 November, also titled Vitality in an Ageing Population. According to Van Bodegom the key to healthy ageing is the lived environment. In the fight against lifestyle-related conditions, he therefore…
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The surgeon who wants to make her operations unnecessary
Lotje Zuur sometimes has to perform disfiguring operations. As a head and neck surgeon, she removes parts of the mouth, throat or face of people with cancer. Now a promising treatment may make such operations unnecessary. What would this mean for patients? This is what her inaugural speech on 19 September…
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Bleeding in hemato-oncology patients
PhD defence
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Red cell transfusion in critically ill patients
PhD defence
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Inflammatory Bowel Disease in Older Patients
PhD defence
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GP in Spain in times of corona
What’s the situation like in Spain in these times of corona? Dr Jan Otto Landman (Medicine, Leiden, 1979) has a GP practice in Torremolinos and Fuengirola, Southern Spain, and since 16 March he has been writing blogs about corona on the Facebook page of his practice. He has covered issues such as the…
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Placebo research: Pharmacological conditioning
The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Clinical Neuropsychology (MSc)
In the specialisation Clinical Neuropsychology, part of the Master in Psychology, you will focus on fostering clinical and scientific skills based on a solid theoretical background as well as practical training in neuropsychology and (clinical) neuropsychological research.
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Euthanasia as a legal question
In the Netherlands, euthanasia has no longer been a criminal offence since 2002. The practice is governed by very strict conditions. Nonetheless, the legal issues surrounding it are still the focus of heated discussion, according to Leiden professors. They are discussing the issue on 18 March during…
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Research
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Building a bridge between data science and the social and behavioural sciences
What is the best living environment for dementia patients? To answer this question, Daniela Gawehns is using data mining methods to search through different types of data source. Her research is inadvertently building a bridge between two disciplines that are sometimes somewhat wary of each other.
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Coronavirus: LUMC media appearances
The staff of the Leiden University Medical Center are doing all they can to help as many corona patients as possible. They are also making regular media appearances to discuss the disease. Below are a few examples.
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Cognitive enhancement: Toward the integration of theory and practice
Cognitive enhancement reflects the use of any (legitimate) means such as for example food supplements to reach one’s personal best.
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Call overview
We are delighted to announce that Speech Prosody 2024 will be held in Leiden, The Netherlands (02–05 July 2024). The conference aims to showcase the facets of prosodic variation and their role in the production, comprehension, and acquisition of speech in order to obtain a better understanding of the…
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Cognitive and behavioural emotion regulation after negative and traumatic life events
To study relationships between emotion regulation after negative and traumatic life events and psychopathology. Within this context, another goal is to develop and validate emotion regulation questionnaires.
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Robots, Healthcare, and the Law
Eduard Fosch-Villaronga, Marie Skłodowska-Curie Postdoctoral Researcher at eLaw- Center for Law and Digital Technologies, just published a book on Robots, Healthcare, and the Law. Regulating Automation in Personal Care.
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Career prospects
A master's degree in Psychology at Leiden University combines theoretical knowledge with academic and professional skills, making you an attractive candidate for many employers.
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Introductie webinar cyber security
Study information
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Neutrino: Documentary & Q&A with the directors
Studium Generale
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Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
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Lifestyle and nutrition to combat diseases (of affluence)
We know this, but we don’t act on it: eat healthily, move more, address our stress levels and sleep well. Internist and Professor of Diabetology Hanno Pijl is fascinated by the effect that a healthy lifestyle can have on health. He researches how this lifestyle is achievable and satisfying, for patients…
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Personalized Medicine
Getting personal
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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Cancer cells: A closer look
What distinguishes a tumour cell from a healthy cell? Researchers are trying to answer this question as precisely as possible. Certain differences could eventually lead to new therapies.
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Research
Research lines within the Pharmacy group:
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Blood vessels on a chip make the cause of dementia visible
New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…
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Development and evaluation of evidence based self-help and online programs for people with a somatic stressor and depressive symptoms
What is the effectiveness of (booklet or online) self-help programmes for people with somatic stressors and depressive symptoms? What works best for whom? How to improve motivation and adherence?
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COMET. Human Subject Research and Medical Ethics in Colonial Southeast Asia
Investigating epistemic and ethical practices in medical experimentation on humans in the colonial period in Southeast Asia.
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Topic: Placebo effects
The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…
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People
The research team
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About the program
In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.
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Boudewijn Lelieveldt: 'AI can help, but not replace, doctors and other healthcare providers'
‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…
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Innovative diagnostics and treatments
The more we learn about a (neuro-)psychological or physical disorder and the related behavioral factors, the better we can not only identify them, but also treat them. It is therefore important that recent insights about (neuro-)psychological problems and related behavioral factors are incorporated…
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Leiden | Islam interview series
The Leiden | Islam interview series contains short documentary-style videos including interview flashes with leading scholars in the field of Islam and Muslim societies. With this series, LUCIS aims to show the value of unconventional insights related to Islam and Muslim societies, and to relate them…
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Quantitative Pharmacology
The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…
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About LUMAN
The Leiden University Medical Anthropology Network (LUMAN) brings medical anthropologists together with the aim of fostering interfaculty collaborations and creating common ground for working interdisciplinary on health-related themes in Leiden and beyond.
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Molecular mechanisms of adverse outcome and translational biomarkers
Adverse drug reactions (ADRs) remain one of the major reasons for patient mortality and (early) drug withdrawal. Currently, different in vivo and in vitro models are used to assess the toxic potential of drugs in the pre-clinical phase. Unfortunately, the predictive value of this model does not fit…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.