1,285 search results for “ancient gene” in the Public website
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Nico Staring
Faculty of Humanities
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Ruurd Halbertsma
Faculty of Humanities
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Valentina Azzarà
Faculteit Archeologie
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Gerard Versluis
Faculteit Rechtsgeleerdheid
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Michael Kerschner
Faculteit Archeologie
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Annelou van Gijn
Faculteit Archeologie
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Luuk de Ligt
Faculty of Humanities
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Alessandro Aleo
Faculteit Archeologie
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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Regulation of nanoparticle biodistribution by scavenger endothelial cells (SECs)
A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…
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Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotor: J.M. Memelink
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Chromatin organization & dynamics (Dr. Remus Dame)
Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…
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Paul Hooykaas
Science
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Urban Craftsmen and Traders in the Roman World
This volume, featuring sixteen contributions from leading Roman historians and archaeologists, sheds new light on approaches to the economic history of urban craftsmen and traders in the Roman world, with a particular emphasis on the imperial period.
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The Archaeology of Greater Nicoya
Two Decades of Research in Nicaragua and Costa Rica
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The Long Arab Conquest of Central Asia: Urban Change in Merv, Paikent, Balkh and Samarkand (651-821)
This PhD research aims to trace the impact of the Arab conquest, both immediate and long-term, on the material and social organization of Central Asia from 651 to 821 through an “urban change” perspective in four cities: Merv, Paikent, Balkh and Samarkand.
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Re-assessing the environmental impact of early Roman expansion
This project aims to explore the environmental impact of early Roman expansion (4th/3rd century BC) through a program of dating and ecological sampling of traces of field systems (centuriations).
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The development of the Proto-Indo-European syllabic liquids in Greek
Ancient Greek was spoken in a large number of different dialects. Although we do not find direct evidence for syllabic liquids in any of our sources, comparative evidence shows that these sounds must have been present in Proto-Greek, and that they were retained until comparatively recently in the prehistory…
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Introducing: Pieter Houten
Pieter Houten is a PhD student in the ERC granted research project 'An Empire of 2000 Cities: urban networks and economic integration in the Roman empire', directed by Luuk De Ligt and John Bintliff (Archaeology).
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Metagenomics for community ecology; a next generation of eDNA monitoring tool for biomass studies in freshwater environments
How can we quantify the density of species within a community through environmental DNA concentrations?
- Laboratory for Ceramics Studies
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Moving Romans. Migration to Rome in the Principate.
Moving Romans offers an analysis of Roman migration by applying general insights, models and theories from the field of migration history.
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Personalized drug repositioning using gene expression
PhD defence
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Research
At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.
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Science for Society
By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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In Pursuit of Next-Generation Lipopeptide Antibiotics
Can new variants of daptomycin and the polymyxins be found?
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
- Leiden Institute of Chemistry
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
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CoSTREAM: Understanding Stroke and Alzheimer
The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. It has long been known that both diseases share underlying causes, but their exact interaction or link is not fully understood. CoSTREAM combines multiple factors to identify and…
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Bacterial Chromatin
The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax
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Neurogenomics of vocal learning
How does FoxP1 affect auditory perception on a behavioural and genomic level?
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The evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
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MeRGeR: Physiological significance of the glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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Solvent tolerance mechanisms in Pseudomonas putida
Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.
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Resolving a bioindicator diatom species complex using genomic approaches for freshwater biomonitoring
This thesis pioneers diatom molecular identification and quantification through genome-scale methods, with four key aims: (i) reviewing DNA/RNA sequencing methods in aquatic biomonitoring to highlight their strengths and limitations;
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More JAZ in the orchestration of jasmonate-mediated plant defense
Promotor: Prof.dr. J. Memelink
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Charlotte van der Voort
Faculty of Humanities