In this volume, Ray Jackendoff and Jenny Audring embark on a major reconceptualization of linguistic theory as seen through the lens of morphology. Their approach, Relational Morphology, extends the Parallel Architecture developed by Jackendoff in Foundations of Language (2002), Simpler Syntax (2005),…

Focus in skin research

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Main challenges in skin vaccination are overcoming the stratum corneum (SC) barrier and targeting the antigen presenting cells (APC) in the epidermis and the dermis.

A vibrant chronology of ceramic manufacturing practices in the valley of Juigalpa, Chontales, Nicaragua (cal 300 CE - present)

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

The MCS research group members and their research are closely affiliated with the two Leiden master’s tracks in Museum Studies offered at the Art History and Archaeology departments.

Current status and future prospects

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Research projects

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…

Mapping the neural mechanisms underlying social motivations of adolescents and adults

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.

This book explores the intellectual and cultural flows between Asia and Europe which occurred during – and were formative of – the political and social changes of the first half of the twentieth century.

Today, everybody and everything produces data. People produce large amounts of data in social networks and in commercial transactions. Medical, corporate, and government databases continue to grow. Sensors continue to get cheaper and are increasingly connected, creating an Internet of Things, and generating…

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

On 25 January 2018 Yannick van den Brink defended his doctoral thesis titled ‘Voorlopige hechtenis in het Nederlands jeugdstrafrecht’ (‘Pre-trial detention in the Dutch juvenile justice system’). The doctoral research is supervised by Professor Ton Liefaard and Professor Mariëlle Bruning.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Open Science means not only sharing final research results but also the underlying data. A main way to do that is by making research data FAIR: Findable, Accessible, Interoperable and Reusable.

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

Faculty of Archaeology, University of Leiden

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

LUCIS is directed by Nathal Dessing, who is advised by a steering committee.

The main question addressed in this thesis is how we can best conceive the contrast between a priori and empirical truths.

Perfect for use at advanced undergraduate and graduate level, this is the first text to offer students a unified narrative regarding the place of the body in Western thinking. The book investigates the ways in which the fact of human embodiment makes the notion of ambiguity central to all major areas…

Most of the PhD graduates (about 70 percent) find a job outside of academia. The majority of them successfully embark on a career in education, administration, heritage, journalism, or business. Other PhD graduates find employment in an academic or semi-academic environment. A considerable number of…

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

Within the broader scope of the interdisciplinary programme 'Social Resilience and Security', we seek to provide a broad and deep understanding of the dimensions and etiology of transgressive behaviours, the effects of interventions, and resilience against such behaviours.

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

To what extent is the legislation and use of pre-trial detention of juveniles in the Netherlands in compliance with international children’s rights standards?

On February 7th, Lotte Dros-Hendriks succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Lotte on this great result.

Few events have influenced our global order as intensely as the events of September 11, 2001.

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

Recently, studies have shown the similarities and differences in sources of meaning between religionists, ‘nones’ and atheists (see several studies of Schnell and others). The present study that will be conducted in three European countries tries to clarify the relationship between meaning giving and…

The Secret Life of Art Works. Exploring the Boundaries between Art and Life is the first collection of essays to present case studies from the visual arts, architecture, sculpture and numismatics, and to engage critically with theoretical perspectives from art history, psychology, aesthetics and ant…

This dissertation investigates ikat from the eastern Indonesian islands from a uniquely technical perspective, including design analysis of asymmetry and microscopy.

Migration is the talk of the town. On the whole, however, the current situation is seen as resulting from unique political upheavals. Such a-historical interpretations ignore the fact that migration is a fundamental phenomenon in human societies from the beginning and plays a crucial role in the cultural,…

The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).

In Indigenous Ancestors and Healing Landscapes Jana Pešoutová presents new interpretations of current healing practices in Cuba and the Dominican Republic juxtaposed against the European colonization of the Caribbean after 1492.

Abrupt Climate Change and Cultural Transformation

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition

This handbook provides a resource for those already familiar with some kinds of micro-particles who wish to learn more about others, or for those just starting out in the study of microremains who wish to have a broad understanding about microscopic archaeology.

Jurisprudence is a philosophical introduction to the law. This subject is taught by the department of Jurisprudence.