Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: E.F. Smets, Co-promotor: J. Geml

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

On 11 May 2016 a prestigious NWO Vidi grant (NWO's Innovation Research Incentives scheme) has been awarded to Nadia Soudzilovskaia for her research proposal entitled “Do mycorrhizal fungi mediate soil carbon fate?”, aimed to understand mycorrhizal impact on soil carbon sequestration.

How do nonmotile microbes leverage communal motility?

The majority (80%) of e-waste generated globally are recycled informally in developing countries.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

PhD defence

PhD defence

PhD defence

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…

Tineke Berkers has won an award for outstanding contribution for her poster at the Gordon Research Conference at Waterville Valley, USA.

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

This project investigates the well-preserved agricultural terraces of the Inn valley and the evolution of resource use in the inner Alps.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Four promising young researchers will be able to conduct two years of research at a university abroad thanks to a Rubicon grant from the Dutch Research Council (NWO). The Leiden laureates are Renske Janssen, Girija Josh, Anne van der Meij and Yana van der Weegen.

A starring role for PhD candidate Andreea Nadaban during the annual meeting of the European Epidermal Barrier Research Network. With her talk about the arrangement of lipid molecules in the upper layer of our skin, she won the award for Best Oral Presentation.

Bacteria and fungi on organic dairy farms are significantly different from those on conventional farms. That was discovered by postdoc researcher Sofia Gomes and her supervisors Nadia Soudzilovskaia and Peter van Bodegom in collaboration with the Louis Bolk Institute and Naturalis Biodiversity Centre.…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Lecture

The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).

This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.

In this article, Friso Selten and Bram Klievink explore how public organisations strategically manage the adoption of AI.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

PhD defence

PhD defence

Can we use indigenous microbial rice communities to reduce methane production in agricultural settings?

This 48-month project is to contribute to a solid, accessible, domestically owned knowledge base for people-centred interventions aimed at strengthening access to justice in Libya (A2JiL), and to disseminate such knowledge among stakeholders, enhancing awareness and the capabilities required to provide…

The research within the Food research programme at CML focuses on a transition towards sustainable food production and consumption systems. We investigate from a very small to a very large scale, at a local, national or international level. We do so by researching for example molecular tools, food systems,…

In 2016, CML published over 90 papers, successfully crowdfunded the Living Lab project, celebrated a royal honour for associate professor Hans de Iongh and contributed to the Global Soil Biodiversity Atlas. CML awarded five PhDs and taught students from all over the world how to contribute to sustainability.…

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…

PhD defence

PhD defence

On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

PhD defence

Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…