1,446 search results for “mechanisms metamaterials” in the Public website
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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LED3 Lecture: Oxygenases - From Mechanisms to Medicines
Lecture
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Dynamical Gibbs-non-Gibbs transitions: a study via coupling and large deviations
Promotores: F.H.J. Redig, W.T.F. den Hollander
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Changing minds in social anxiety: A developmental network approach to neurocognitive bias modification
Which adolescents are more at risk of developing social anxiety disorder later in life?
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Nitric oxide in defence against mycobacterial infection
Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?
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R-ELEVATION
How do plant defense genes get activated?
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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Quantum to Classical
In Quantum mechanics, particles can be in multiple positions simultaneously. Yet, when a measurement is made, the particle is found only in one place. Technology has come to a point where we may design experiments that will tell us how.
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Topic: Placebo effects
The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…
- Prof Dr André Kessler
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New publication on dispute settlement by Christa Tobler under EU Association regimes
The EEA enforcement system includes, in particular, the mechanism pursuant to Article 111 EEA for the settlement of disputes between the Member States with respect to the interpretation and the application of EEA law.
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On shape and elasticity: bio-sheets, curved crystals, and odd droplets
Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.
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New generation alum based vaccine adjuvants
Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.
- Dr Heiko Vogel
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
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Towards an ab-axis giant proximity effect using ionic liquid gating
In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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Srebrenica and the Search for Justice
National and international actors have attempted to provide accountability for the events at Srebrenica in July 1995. This research project aims to draw lessons learned from those multiple efforts in assessing whether securing a measure of ‘justice’ for the victims has been successful and how national…
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New publication on arbitration in the EU's external relations
‘Schiedsgerichte in den Aussenverträgen der EU. Neue Entwicklungen unter Einbezug der institutionellen Verhandlungen Schweiz–EU’, Jusletter 28 May 2018
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Metabolomic characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation
Source: PLoS ONE, Volume 10, Issue 3 (2015)
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Adsorption and catalysis on Pt and Pd monolayer-modified Pt single crystal electrodes
The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.
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The more the better? The complementarity of United Nations Institutions in the fight against torture
This article devises a framework to assess the degree to which human rights bodies provide duplicating or contradicting recommendations to States. Focusing on the case of torture, it creates an original database of recommendations delivered to 14 countries in the years 2012–2016. Results show that duplications…
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice
Miriam Cohen defended her PhD dissertation entitled “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” on 28 June 2017. She wrote her thesis under the supervision of Professor L.J. van den Herik and Professor C. Stahn.
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Smoothly breaking unitarity : studying spontaneous collapse using two entangled, tuneable, coherent amplifiers
The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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Evaluation of the Law Ombudsperson for Children
To what extent does the Law Ombudsperson for Children achieve its goals as intended by the legislator when introducing the law?
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Duality, bosonic particle systems and some exactly solvable models of non-equilibrium
Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander
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Searching for an explanation for remarkable behaviour of ice on Earth
If you replace the standard hydrogen atoms in ice with a heavier variant, something odd happens. The volume occupied by the molecules increases by 0.1 per cent. Leiden chemist Jörg Meyer and his colleagues have created a theoretical model that describes this behaviour. Their research appeared on the…
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Vibration Isolation
To be able to measure small forces or small deviations from Boltzmann, the external vibrations at the resonance frequency must be very low. To achieve this, we have developed a very soft vibration isolation system and combine it with several other measures to reduce vibrations in our dilution refrigerators.…
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The role of expectancies and avoidance learning in the maintenance of somatic symptoms
Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.
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Development & Disease in Plant Sciences
Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…
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Research
The aim of the research programme is to provide insight into the cognitive processes and brain mechanisms that underlie reading, arithmetic and learning in general.
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Banking Regulation in and for Crisis
In this article, Lydie Cabane, Assistant Professor at the Institute of Security and Global Affairs, and Martin Lodge address the question of how to manage banking crises, a question that has gained prominence since the banking crisis of 2007-2009. This article sets out the rationale for regulating for…
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Cultural evolutionary modeling of patterns in language change. Exercises in evolutionary linguistics
This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
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Transnational and Cross-Cultural Agents in the 17th Century Overseas Expansion
Why is Crossnational and Cross-cultural agents such as Henrich Carloff and Willem Leyel important when studying Early Modern expansion?
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Electroreduction of nitrate and carbon dioxide on copper electrodes: a mechanistic study
In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…
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The Lead Zeppelin
As an alternative to the diving board shaped force sensor, we are now developing a magnetically levitated small superconducting particle – or ‘Lead Zeppelin'' – as our mechanical resonator. We explore routes towards detection of gravity between small objects.
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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A study on PsbS and its role as a pH sensor
Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.
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‘Non-Istanbulites’ of Istanbul: Quest for a place in Istanbul in the Turkish novel since the 1960s
This research focuses on a historical/social analysis of a selected corpus of novels from modern Turkish literature which have the common theme of migration from Anatolian towns and villages to Istanbul, and the immigrants’ struggle in this city against various exclusion mechanisms.