976 search results for “li is crystal” in the Public website
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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Surface Reactivity of Activated CO2 Selective use of energy in splitting CO2
Juurlink
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Leiden Institute of Chemistry
The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…
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On Display: Instagram, the Self, and the City
Discover the impact of Instagram on our daily lives in the book On Display. Boy and Uitermark delve into the platform's influence on our social interactions.
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Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining β-Exoglucosidases In Situ and In Vivo
A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…
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VARIS
When does it rain when air is oversaturated with moisture? How does an infection spread among the population? The problems that mathematician Professor Frank den Hollander tries to solve come from physics, chemistry and biology.
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Cyclophellitol and its derivatives: synthesis and application as beta-glycosidase inhibitors
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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BioTherapeutics
Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Star-Forming Galaxies at the Cosmic Dawn
Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens
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Towards efficient low-temperature CO2 electrolysis
In what way can the chemical properties of cobalt porphyrines be adjusted to optimize their selectivity and activity when using them for the electrochemical conversion of CO2 to methane and methanol?
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Staring at the heavens: Astronomy in medieval Islam
University Lecturer Ahab Bdaiwi:
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Biotherapeutic Delivery
The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…
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Word order, information structure and agreement in Teke-Kukuya
PhD defence
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Aspects of the analysis of cell imagery: from shape to understanding
In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.
- China's Diplomacy
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Italic, Celtic, and what lies beneath: Talks on the occasion of Andrew Wigman's defense
Conference
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Inverse Agonism and Constitutive Activity
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John Mydosh and the mystery of the Hidden Order
A 35-year-old uranium crystal will not disclose its secret: what causes a dramatic phase transition at 17.5 Kelvin? Thanks to a new artificial intelligence approach, half of the possible explanations are excluded, but the definitive answer remains to be found. 'It is very frustrating', says physicist…
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Dynamic Capacity Investment under Competition
What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?
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Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling
The close interaction between organic chemi stry and biology goes back to the late 18th century, when the modern natural sciences began to take shape. After synthetic organic chemistry arose as a discipline, organic chemists almost immediately began to pursue the synthesis of naturally occurring compounds,…
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Accessing End-Of-Supply Risk of Spare Parts Using Big Data
How to access the end-of-supply risk of spare pares using big data analytics
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Respiratory-chain enzymes
Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.
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The scientists behind LED3
LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.
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CBAC & MCBIM Reunion for PhD students and Postdocs
Alumni event
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Organisation
Research and education at the Leiden Institute of Chemistry is overseen by the Institute Board. The Board and representatives of the two research themes form the Management Team. The Scientific Council (WERA), the Institute Council (I-Raad) and the platform for PhDs and post-doctoral co-workers (LIC73)…
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Interview with Rector Hester Bijl: ‘There is no place for antisemitism here’
Leiden University is under fire: it is allegedly doing too little to tackle antisemitism. Rector Hester Bijl responds to this accusation and to a video from 2014 on social media in which extreme remarks are made. ‘We can be short about such comments: they are unacceptable. The university is and always…
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Grave Reminders
Comparing Mycenaean tomb building with labour and memory
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Berichtigungsliste der Griechischen Papyrusurkunden aus Ägypten, Dreizehnter Band
Berichtigungsliste der Griechischen Papyrusurkunden aus Ägypten, Dreizehnter Band. Herausgegeben von F.A.J Hoogendijk und A. Jördens. Zusammengestellt von J.M.S. Cowey und F.A.J. Hoogendijk (Leiden-Boston, Brill, 2017).
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Current and next generation influenza vaccines: Formulation and production strategies
Vaccination is the most effective method to prevent influenza infection. However, current influenza vaccines have several limitations. Relatively long production times, limited vaccine capacity, moderate efficacy in certain populations and lack of cross-reactivity are important issues that need to be…
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Foodways in early farming societies
Microwear and starch grain analysis on experimental and archaeological grinding tools from Central
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Cosmic tomography with weak gravitational lensing
We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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The Early and Middle Pleistocene Archaeological Record of Greece
Current status and future prospects
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United in incoherence – Private law concepts under pressure from European financial law
Just published: United in incoherence – Private law concepts under pressure from European financial law (in Dutch), in: Tijdschift voor privaatrecht 2017-4
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China Region Group
The China Region Group develops and monitors Leiden University's cooperation with China. It is chaired by the Dean of the Faculty of Science, Prof. Jasper Knoester, and consists of representatives of Leiden University's faculties and various policy departments.
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Shifting Identities - The Musician as Theatrical Performer
The focus of the research lies in the approach of reducing, denying, or taking away essential elements of music making in order to let the musician become theatrical.
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The Texture of the Lexicon
In this volume, Ray Jackendoff and Jenny Audring embark on a major reconceptualization of linguistic theory as seen through the lens of morphology. Their approach, Relational Morphology, extends the Parallel Architecture developed by Jackendoff in Foundations of Language (2002), Simpler Syntax (2005),…
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Inter-creditor equity in sovereign debt restructuring : towards the establishment of a multilateral legal framework
This dissertation explores the relationship among creditors in sovereign debt restructuring and specifically focuses on the issue of inter-creditor equity.
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Ultrasensitive in situ visualization of active glucocerebrosidase molecules
Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…
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Molecular inheritance from cloud to disk: a story of complex organics and accretion shocks
Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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How to find LMUY room 4.28
Room 4.28 in the LMUY Building is a dedicated lecture room for the Media Technology MSc program. Finding it for the first time may be challenging. Below is a description of how to find it.
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Global Music: recasting and Rethinking the Popular as Global
Vertrekkend vanuit een communicatief perspectief en concentrerend op mediatiseringsprocessen, formuleert deze dissertatie een alternatief voor het probleem van equivociteit binnen de studie naar populaire muziek.
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Working on Labor. Essays in Honor of Jan Lucassen | Studies in Global Social History, Volume: 9
This collection of seventeen essays takes its inspiration from the scholarly achievements of the Dutch historian Jan Lucassen. They reflect a central theme in his research: the history of labor.
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Tlamatiliztli: la sabiduría del pueblo nahua. Filosofía intercultural y derecho a la tierra
The aim of this research is the systematic analysis of the wisdom coined by Nahua people of Mexico, based on the historical sources and archaeological evidence, but also in the knowledge developed by contemporary indigenous communities and the contributions of indigenous scholars.
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Socially Embedded AI Systems
This interdisciplinary research project explores several adaptive machine learning methods which can give insight into the interaction between human and machine. The ultimate goal is open and natural communication between humans and AI that should result in mutual trust, cooperation and coordination…
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Quantum computation with Majorana zero modes in superconducting circuits
Promotor: C.W.J. Beenakker, Co-Promotor: A.R. Akhmerov
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A connected history of eastern Christianity in Syria and Palestine and European cultural diplomacy (1860–1948)
This special issue of Contemporary Levant critically explores, at a micro and macro level, the structural role and religious, cultural and political interactions of the Greek-Orthodox, Melkite and Syriac communities in late Ottoman and Mandate Syria and Palestine.
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Political Religion Beyond Totalitarianism
The eleven innovative essays in this volume explore the notion that all forms of modern mass politics, including liberal democracies, need such a form of sacralization of politics to function.