621 search results for “immuniteit infection en tolerance” in the Public website
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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van de partijkeuzes in CPB-doorrekeningen van verkiezingsprogramma's en regeerakkoorden, 1986-2017
This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.
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Conferencia de Margarita Mateo en Leiden
Es un placer y un gran honor poder contar con la participación de la Prof.dr. Margarita Mateo Palmer durante el X Congreso Internacional de la AHBx. Impartirá una conferenica plenaria bajo el título “Nombrar las cosas: avatares transhispánicos en Cuba” el Jueves 2 de Noviembre a las 9.45 en el edificio…
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Even voorstellen: Geerten Waling en Anne Heyer
Sinds september 2010 werken Geerten Waling en Anne Heyer in het NWO project ‘The Promise of Organization’.
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INFLANET - Training European Experts in Inflammation: from the molecular players to animal models and the bedside
How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?
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Leiden University and LUMC join Netherlands Centre for One Health
Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.
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Hoe thermostaat en tv cyberwapens konden worden
Geheime diensten en criminelen kunnen inbreken in slimme apparaten, door slechte beveiliging. De markt lost het niet op: bedrijven willen gadgets verkopen, burgers doen ook weinig. NRC sprak hierover met Bibi van den Berg.
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Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
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Microbial Induction of Plant Resilience to Drought Stress (MicroRes)
What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?
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Journalistiek in Irak tweegesprek met Judit Neurink en Sakir Khader
LUCIS organiseerde op woensdag 4 maart een speciale avond over journalistiek in Irak. Journaliste Judit Neurink en programmamaker Sakir Khader vertelden over hun ervaringen en recente werkzaamheden in het land. De avond stond onder leiding van Wendelmoet Boersema (politiek redacteur van dagblad Trou…
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Gezocht: Vertegenwoordigers in de Commissie Onderwijs en Onderzoek
Als vertegenwoordiger behartig je de belangen van promovendi en ReMa-studenten binnen de Onderzoekschool Mediëvistiek. Zo krijg je onder meer de kans om mee te denken over het verbeteren van de onderwijs- en onderzoeksactiviteiten van de onderzoekschool. Interesse? Nog vragen? Neem contact op…
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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About this minor
Everything you need to know about the minor Ecology, Migration and Tolerance: Limits to Cooperation.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Maria Yazdanbakhsh
Faculteit Geneeskunde
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Dutch East and West India Companies in the Hoge Raad van Holland, Zeeland en West-Friesland
How did free agents oppose the monopolies held by the VOC and WIC in court?
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Journée d'étude en mémoire de Jean-François Gilmont
Le Centre d’études supérieures de la Renaissance (Tours) organise une journée d'études en mémoire de Jean-François Gilmont (1934-2020).
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Student projects
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Joost Frenken on Radio 1 Langs de Lijn en Omstreken
Physicist Joost Frenken was interviewed on the radio show 'Langs de Lijn en Omstreken' (Radio 1) about the recent discovery of superconductive graphene. The one-atom-thick material was already known for its strength, flexibility, lightweight and good conductivity.
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Ton Koopman Huizinga Lecture 2016 ‘Bach en zijn zangers’
On December 9, 2016 Prof.dr. Ton Koopman will give a lecture 'Bach en zijn zangers' in the Pieterskerk in Leiden.
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Spreading the Fire: Why is Pyroptotic Cell Death Contagious?
The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Smartmix: A new generation of efficient biomedical research
Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Conferencia de la Prof.dr. Sayak Valencia en el X Congreso Internacional de la AHBx
El viernes 3 de noviembre a las 11.15 tendremos el gusto y honor de escuchar a la Prof.dr. Sayak Valencia en el marco del X Congreso Internacional de la AHBx. Prof.dr. Sayak Valencia (Tijuana, Mexico, 1980) impartirá la segunda conferencia plenaria del X Congreso Internacional de la AHBx bajo el título:…
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Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?
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Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
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Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity
The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
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Staying Ahead of the Virus
In STAYAHEAD data-intensive approaches are being developed to ”decode the human immunome” with a focus on a global vaccine strategy. They have developed a rapid mass spectrometric test to analyse in real-time large numbers of variants of SARS-CoV-2 and the host immune response, and use these data to…
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Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
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Live or let die: the intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?
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Inkomen en afkomst zijn risicofactoren bij kans op hart- en vaatziekten
Nederlanders met lage inkomens lopen tot 1,5 keer meer risico op het krijgen van een hartaanval of beroerte dan rijkere landgenoten. Bij Surinaamse Hindoestanen is dit risico 1,9 keer hoger. Dat blijkt uit onderzoek van het LUMC en het HagaZiekenhuis. Nederlandse artsen kijken tot nu toe niet naar deze…
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Crime and Migration in an Age of Transformation
The nineteenth century truly was an age of transformation. Throughout Europe processes of industrialization and urbanization, nationalization and centralization, changed the structures of society. It was an age in which the number of people living in urban communities grew substantially.
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Diagnosis of tuberculosis infection before immunosuppression
PhD defence
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Een dag vol (nep)skeletten en mammoettanden
De Faculteit Archeologie bestaat dit jaar 25 jaar. Ter ere van dit jubileum opende de faculteit op 1 maart zijn deuren voor het brede publiek.
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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Efficient and flexible platform to isolate and study bacteriophages
We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.
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Global metabolomics and lipidomics approaches to probe virus-host interactions
The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.
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A much-needed new class of antibiotics
Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Translational Immuno-Pharmacology
The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…
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The immune system: step it up or slow it down?
When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…