1,707 search results for “cardiovascular diseases” in the Public website
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Analysing diseases through interactive visual interfaces
Alzheimer’s disease and cancer are two examples of diseases that are related to malfunctioning cellular patterns. The examination of cell tissue, however, takes a lot of time and generates a lot of data. To make the analysis of data easier, Antonios Somarakis of the Data Science Research Programme (DSRP)…
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800 year old mystery of ancient bone disease solved
Scientific research at the molecular level on a collection of medieval skeletons from Norton Priory in Cheshire, United Kingdom, could help rewrite history after revealing they were affected by an unusual ancient form of the bone disorder, Paget’s disease. Osteoarchaeologist Carla Burrell, attached…
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…
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A game of Mastermind to unravel Alzheimer’s disease
In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…
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Detecting diseases with molecules in the body
Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Preventing or curing diseases with X-omics
In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…
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Advocating for gene therapies for rare diseases
‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…
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Seeking new concepts to treat diseases
Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’
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Single gold nanorods in live cells
Visualization of biomolecules in living cells by tagging with gold nanoparticles.
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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Key publications
Key publications of the Cardiovascular Pharmacology group
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Better understanding of disease thanks to organs-on-chips
For medical research, researchers often recreate tissue in the lab. Organ-on-a-chip technology emulates organs, right down to the blood that flows through them, thus creating a realistic test model for drugs or research into disease processes. Researchers from the LUMC are coordinating an NWO Gravitation…
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Willem Fibbe
Faculteit Geneeskunde
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VICI grants for five Leiden researchers
Research organisation NWO has awarded a VICI grant to five Leiden researchers. In total, 32 leading researchers in the Netherlands have been awarded a VICI grant.
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Vascular and Regenerative Medicine
Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…
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Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
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Curing diseases with lab-grown organs
Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Bacteria inside plant roots battle fungal disease
Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…
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Draw on behavioural science for a healthy lifestyle
Healthy lifestyle campaigns are often unsuccessful. It is hard to get people to eat healthily or do more exercise. Behavioural science expertise should be drawn on at a much earlier stage in policy development, say twelve behavioural scientists in a position paper. They will present the paper to Maarten…
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Horizon Europe grant for research into personalised treatment for high blood pressure
Professor Thomas Hankemeier and his international research team HYPERMARKER have received a 10m-euro grant from Horizon Europe and UK Research and Innovation.
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Metabolomics Facility officially in operation
The Metabolomics Facility of Leiden University is now officially in operation to prevent disease and to improve health throughout the human lifespan.
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Maternal mortality in the Netherlands halved in recent years
The number of women in the Netherlands dying before, during or after childbirth has halved.
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AI in Neuroscience: Development of Methods to make Personalized Predictions for Migraine and Stroke from E-Health Sensor Data
The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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‘Coeliac disease diagnosis is often overlooked or delayed’
Although coeliac disease, an autoimmune disorder that makes you gluten intolerant, occurs in 1% of the population, its diagnosis is often delayed or completely overlooked. To prevent health problems, this must change. That is what Professor of Paediatrics Luisa Mearin said at her inaugural lecture on…
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Elizabeth (Liesbeth) de Lange
Science
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‘A revolution is coming in treatments for neurodegenerative diseases’
Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.
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‘Mysterious Meniere’s disease is the poor relation in medicine’
Meniere’s disease, a disorder of the inner ear, was first described back in 1861, but there’s still no good test or treatment for it. Tjasse Bruintjes, Professor by Special Appointment of Ear, Nose and Throat Surgery, wants more attention for this mysterious disease. And he wants to tell his fellow…
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Bio-inspired engineering to fight emerging viral diseases
Leiden Scientists are getting prepared to tackle future epidemics. A group of scientists led by Dr. Alireza Mashaghi has used innovative engineering approaches to make the first “Lassa Hemorrhagic Syndrome on-a-Chip”. World Health Organization has listed Lassa fever among diseases that pose the greatest…
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10 million for research into disease transmission by mosquitoes
How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…
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Decomposing tears in order to detect Dry Eye Disease
By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…
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NWO grant for super fast analysis of disease progression
New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.
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Deciphering the link between Iron and Brain Disease
Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Nanoplastics found throughout the human body – how worried should we be?
The world is becoming clogged with plastic, with tiny plastic particles found everywhere, from the oceans’ depths to the mountain tops, soil, plants, animals and even inside us. The question is: what harm, if any, are they causing? In a new article on The Conversation, environmental scientists Meiru…
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Redesigning Cardiovascular Healthcare
PhD defence
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Sensing & Stimulation (MSc)
In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…
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Better treatment of systemic autoimmune diseases requires close collaboration
Exceptional collaboration between physicians is needed to better understand and treat autoimmune diseases that cause inflammation in various organ systems.
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Using zebrafish to target the Achilles’ heel of cancer
Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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Perception of multidimensional speech sounds in humans and songbirds
Do humans and zebra finches share cognitive mechanisms that are important for speech perception?
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Neurogenomics of vocal learning
How does FoxP1 affect auditory perception on a behavioural and genomic level?
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Collaborating on big data to unravel disease processes
Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.
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Changing enzymes for clean energy and disease prevention
They can play a role in metabolic disorders and can break down tough plant fibers: β-glycosidases are enzymes that play many roles in nature. Fredj Ben Bdira changed these enzymes in order to enhance the production of clean energy and to improve the treatment of patients with metabolic diseases.
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Inaugural lecture: Research into accelerating rare disease research through registries
On 3 April, Professor Syed Faisal Ahmed from the Leiden University Medical Center (LUMC) will give his inaugural lecture ‘Strength in Numbers’. He will emphasise the benefit of registries to rare disease research.
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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Targeting Inter-Organ Cross-Talk in Cardiometabolic Diseases
PhD defence
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Maia Casna
Faculteit Archeologie