Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Promotores: J. Jonkers, K.E. de Visser

PhD defence

This thesis investigates the syntax of object marking in Sambaa and the Bantu languages in general, with particular focus on Swahili and Haya, as points of comparison.

This dissertation investigates whether and how gradability is manifested in the nominal domain, as well as the implications this could have for theories of the representation of gradability.

Social anxiety runs in families, but the neurobiology underlying this genetic vulnerability is until now largely unknown. The unique Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) aims to broaden our knowledge with respect to this genetic susceptibility.

The aim of the project is to unravel the genetic and contact relations between the indigenous languages of Mesoamerica (Mexico and western Central America) and the Middle Andes region (Ecuador, Peru, Bolivia), as part of a larger endeavor to understand the historical process of the peopling of the Americas…

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

Evolution & Biodiversity is one of the four research themes of the Institute of Biology Leiden.

The students of iGEM Leiden 2021 have scored well in the eponymous biology competition: they won a Gold Medal and the Best Safety & Security Award. The student team received the awards for their project DOPL LOCK, in which the team tries to make genetic modification safer.

Lecture

The Rob Schilperoort Memorial will be unveiled at the Leiden Bio Science Park on Saturday 16 September. This gigantic gate stands at the entrance to the park, which is also named after Schilperoort, its founder.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

This research intents to redefine the limits of the electric guitar.

Examining the therapeutic potential of new semisynthetic lipopeptide antibiotics

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

From basic science to real-world interventions

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

Getting personal

Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.

A linguistic test of hypotheses rooted in genetics and archaeology.

Find out how to apply for Molecular Genetics and Biotechnology at Leiden University by following our step-by-step guide.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Challenges for the protection of traditional knowledge and genetic resources, traditional cultural expressions, and traditional knowledge of indigenous peoples in the international scenario.

Do you have questions about the master’s specialisation Molecular Genetics and Biotechnology? Please contact us.

Do understudied animals contain hidden species?

Antwoord op veelgestelde vragen over onderzoek met proefdieren bij de Universiteit Leiden. FAQ

Various companies in the plant biotech industry will test a recent Leiden discovery in their crops. The ‘Pol Theta’ technology is developed in Leiden and makes it possible to reduce undesired side effects during genome engineering of plants.

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The specialisation consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30 - 60 EC) and and one or more research projects (60 - 90 EC).

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

PhD defence

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

A novel in vivo model system for studies on glucocorticoid resistance

Palaeography of an ancient nomadic writing culture

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Which intervention technique is more effective in reducing public speaking anxiety in children aged 9 – 12 years, exposure or restructuring cognitions?

As part of the process of safeguarding the quality of our research, our institutes are audited regularly by a committee of external experts.

Promotor: P.D. Grünwald