Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Supervisor: Gerard van Westen

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Biotherapeutics or biologics, such as proteins, peptides, and nucleic acids, comprise an increasing share of the pharmaceutical market, whilst offering new therapies for difficult-to-treat diseases. Most notable is their contribution to the vaccination efforts during the COVID-19 pandemic. In most cases,…

Professor at the Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria - South Africa

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

School of pharmaceutical sciences, University of Geneva - Switzerland

Where did species survive the cold cycles of the current Ice Age?

The Biological- and Soft-Matter Physics specialisation is an excellent preparation for pursuing a PhD degree in physics.

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

This thesis describes the evaluation of novel natural products with antibacterial activity enabled by total chemical synthesis.

Source: The AAPS journal, Volume 16, Issue 4, pp. 681-684 (2014)

Tuberculosis is an infectious disease which is spreaded through the air. It is caused by Mycobacterium tuberculosis and it led 1.7 million people to death in 2016. This mortarlity rate is concentrated in developing countries such as Indonesia, Philippines, Pakistan, and South Africa. These numbers make…

Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…

Japanese newspapers, photo archives from the Dutch East Indies or information on gender and sexuality: all these can be found in the University Library's 621 humanities databases. A flyer campaign to raise awareness of them begins this week.

This summer, the COBRA Museum will be focusing on Moroccan art. 'The other story' exhibition presents for the first time Moroccan modernism in the Netherlands. The Netherlands Institute Morocco (NIMAR) contributed to its exhibition

What are International Studies Alumni doing after graduation? Get to know Guido, Paulien and Lennart. They all studied International Studies at Leiden University in The Hague and are now working in three different fields.

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

Nadine Raaphorst, university lecturer at the Institute of Public Administration, has been awarded a Veni-subisidy from science financier NWO. This grant of up to 250,000 euros will enable her to set up her own research in the coming years. Raaphorst's research is about consistent decision-making by…

Lecture

The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…

Three of the four Heineken Young Scientists Awards for 2022 have gone to researchers from Leiden: chronobiologist Laura Kervezee, physicist Jordi Tura i Brugués and health psychologist Liesbeth van Vliet.

Lecture

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

The aim of our research program is to better understand the etiology and course of mood, anxiety and stress-related disorders, such as depression and posttraumatic stress disorder (PTSD). We investigate both the transdiagnostic mechanisms underlying these disorders and work on improving the treatments…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

The Division of BioTherapeutics at the Leiden Academic Centre for Drug Research (LACDR) is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…