Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

The research master's specialisation Developmental Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

PhD defence

PhD defence

PhD defence

The Centre for Indigenous America Studies (CIAS) at Leiden University is designed to coordinate and promote the teaching and research of Indigenous languages, literatures, cultures and cultural heritage.

It is mostly rainfall and soil acidity that determine which microbes survive in a particular habitat and which do not. This knowledge is important for maintaining biodiversity. Leiden environmentalists contributed to the research. Publication in Nature on 1 August.

The Centre for Indigenous America Studies (CIAS) at Leiden University is designed to coordinate and promote the teaching and research of Indigenous languages, literatures, cultures and cultural heritage.

The Life in Custody (LIC) Study comprises a large-scale research project into prison climate and the quality of prison life in Dutch prisons.

There must be a reason why there are 90,000 international students in the Netherlands, a number that is increasing every year. In fact, there are several very good reasons.

Students are welcome to come to LUC as an exchange (non-degree) student for either one semester or a full year. Please realise that choosing LUC as your sermester abroad destination means you take up all of your courses at LUC.

Leiden Law School offers an extensive range of English-taught law courses at undergraduate level. These are open to both Dutch and international students alike, giving them a truly international flavour.

Would you like to stay with us a little longer after your exchange programme? If so, take a look at our extensive selection of English-taught 1 or 2 year Master's programmes.

PhD defence

PhD defence

Promotores: J.C. van Houwelingen, S.A. van de Geer

Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

The applications of studying the early development of insects range from agriculture to material science.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.