2,821 search results for “gene and plant studies” in the Public website
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Liver X receptor: therapeutic targeting of common pathways in Psoriasis and Cardiovascular co-morbidities
Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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A community computational challenge to predict the activity of pairs of compounds
Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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CAM-PaC
The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…
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Mechanical and genetics basis of cellularization and serosal window closure in Tribolium castaneum
The applications of studying the early development of insects range from agriculture to material science.
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen
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Unraveling the mechanism of multicopper oxidases: from ensemble to single molecule
Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma
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The Ecology and Evolution of Microbial Warfare in Streptomyces
The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame
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Research
The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.
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ACTION
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…
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Systems Pharmacology
The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Biological and Soft Matter Physics
Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Cryptic species discovery
Do understudied animals contain hidden species?
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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New dimension to coral research
For the first time, international researchers have mapped the network of bacteria on coral reefs. They write about it in Nature Communications (9 April). Professor by special appointment Nicole de Voogd (Naturalis Biodiversity Center & Institute of Environmental Sciences) and two of her PhD students…
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Leiden University and Naturalis join forces to launch new ‘Evolution Today’ MOOC
Evolution is all around you every day. This is the message of the new Massive Open Online Course (MOOC) of Leiden University and Naturalis that begins on September 19.
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MOOC ‘Evolution Today’
Evolution is all around you every day. This is the message of a Massive Open Online Course (MOOC) of Leiden University and Naturalis that is offered free of charge to anyone interested.
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Famous Leiden scientists
The oldest university in the Netherlands has produced many well-known scientists. Some of them are known to the wider public; others are perhaps less well known, but their achievements are no less impressive.
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Religion and Orientalism in Asian Studies
Religion and Orientalism in Asian Studies analyses the role of religion in past and present understandings of Asia.
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CRB1 gene therapy coming of age: Mechanistic insight and rAAV assays on mouse & human retinal organoid models
PhD defence
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Shepherding precision gene editing with CRISPR-Cas9 variants and adenoviral vectors
PhD defence
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Leiden University Shi'i Studies Initiative (LUSSI)
Shiʿi Islam
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Oude Nabije Oosten-studies
This programme video is presented in Dutch
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Amazonian word lists
Publication of Johann Natterer's (1787-1843) word lists of Amazonian languages.
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Ecotox
Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…
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Advisory Board
The Advisory Board of the IBL consists of five eminent scientists with specialist expertise in complementary disciplines. They all have prominent positions for the field of Biology in the Netherlands outside our own institute.
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Partners of the Leiden Slavery Studies Association
The Leiden Slavery Studies Association cooperates with the following partners:
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Leiden Jewish Studies Association Thesis Prize
The Leiden Jewish Studies Association awarded the inaugural “Best Thesis in Jewish Studies” in December 2023.
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Book and Digital Media Studies (MA)
The master’s programme in Book and Digital Media Studies introduces you to the history of the written and printed word, and to theories and practices of publishing as well as digital textual media.
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Pepita Hesselberth
Faculty of Humanities
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Crystal Ennis
Faculty of Humanities
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Research
The Forensic Family and Youth Care Studies research group conducts innovative high-quality research aiming to gain knowledge about deviant developmental trajectories of vulnerable children, adolescents, and families, about how to prevent problematic development and how to intervene when necessary.
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Hebrew and Aramaic Studies (research) (MA)
The research master's in Hebrew and Aramaic Studies, a specialisation of the Classics and Ancient Civilizations (Research) programme, at Leiden University explores Classical Hebrew and Aramaic Studies in the broadest sense.
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Centre for Science and Technology Studies
How do you ensure that research is performed, evaluated and managed in a responsible way? This question is also of the utmost important to the University itself. The Centre for Science and Technology Studies (CWTS) studies scientific research and its relationship with technology, innovation and soci…
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LUCSoR : Centre for the Study of Religion
Leiden University Centre for the Study of Religion (LUCSoR) studies religion as human activity, in all its diversity.
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About the programme
As a student in Security Studies you are a socially engaged critical thinker eager to study real-life security cases in an academic setting. You focus not just on the broad context of these issues but also on the role of government, institutions and media. Want to know more? Sign up for one of our Open…
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History and International Studies 1900-Present
The research programme History and International Studies 1900-Present addresses the interconnections and interdependence of contemporary global political, economic and cultural affairs from a multidisciplinary perspective rooted in the humanities.
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Trans-species perspectives on African Studies
In the last couple of decades an ‘animal turn’ has taken place in the social sciences. This has led to a call to study social issues by including non-human animal perspectives. This Collaborative Research Group thinks it's high time that African Studies joins the chorus of minds that try to contribute…