Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Promotor: W. Jiskoot, Co-promotor: A. Hawe

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

In this project, we use social network analysis to analyze the behavior of users in online forums and associated marketplaces over time.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

To achieve a more consistent and professional look in our scientific posters. A new template has been chosen. This design and its principal elements can be downloaded here.

Can we link multiple components from herbal extracts with their biological activities?

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

What are the differences between the trade in Chinese herbal drugs in Europe between 1800 and now? Can we see the major metabolic changes after 200 yours?

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Control of infectious diseases poses continuous challenges for human health.

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Dr. at the Department of organic chemistry, Wageningen University - the Nederlands

This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.

FIJI is one of the most used image analysis tools in the world. FIJI stands for FIJI is just ImageJ, it is however much more.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

The research at The Metabolomics & Analytics Centre is centered around developing innovating analytical methods to enable metabolomics-driven systems biology in personalized health strategies.

On the 26th of September, Cosmas Rai Amenorvi successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Cosmas on this achievement!

Leiden University research institutes based in Leiden and The Hague.

In 2020, many of our staff and students have again won prestigious prizes and been awarded important research subsidies.

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

Premature babies almost always require treatment with medication. Doctors usually determine the dosages based on data from children who were not born prematurely, while preterm infants often develop differently. Medication researcher Aline Engbers investigated three commonly used drugs, focusing on…

How do religious narratives persuade their readers to believe their message? And how can it be that some readers even come to treat fantasy and science fiction as authoritative religious texts? These are the core questions treated in Markus Davidsen’s new book Narrative and Belief: The Religious Affordance…

With Leiden University Press, LUCIS publishes a peer-reviewed book series “Debates on Islam and Society” aimed at a broad audience. A number of books in this series are available in open access.

Negotiation can only really be an alternative to warfare, if the parties agree on a framework of rules and procedures. And if the confidence of the partners may increase in another. But negotiations continue to wage war by peaceful means.

Humanities are needed to make sense of social issues. Watch or listen to the stories of our experts who tell about their research and the impact on society. Get to know the world at Humanities!

This open access volume surveys the state of the field to examine whether a fifth wave of deterrence theory is emerging. Bringing together insights from world-leading experts from three continents, the volume identifies the most pressing strategic challenges, frames theoretical concepts, and describes…

The combination of academic and professional skills taught in the CSM prepares you for a wide variety of careers in the rapidly expanding domain of security and crisis management, including public or private sector and policy-making positions.

William Lippert investigates the effect of delegation to an agreement executor on success of conventional arms control agreements in Europe.

The second and final volume of this co-authored study has just been published by J.B. Metzler. This second monograph explores the history of the concept of barbarism in the twentieth and twenty-first centuries.

As a critical commemoration of its centenary, this book presents a mosaic of one hundred carefully curated fragments by expert authors, shedding light on politics, economy, society, culture, gender, and arts in a hundred years of Turkey.

The specialization Peace, Justice and Development at Leiden University examines the legislation that governs international relations in a global society.

Subproject of the ERC project 'Challenging the Liberal World Order from Within: The Invisible History of the United Nations and the Global South'.

In the Master's programme Crisis and Security Management, you will study contemporary security challenges from both local and global points of view, gaining a deep understanding of the ‘wicked problem’ of security and crisis topics in a complex and globalising world.

Leiden University will be conferring three honorary doctorates in its special anniversary year. They will be awarded to Eliot Higgins, truth finder and founder of Bellingcat, Bonnie Honig, expert in feminist theory and legal theory, and Kelly Chibale, professor of organic chemistry, who works on prevention…

The nominees for the IRO Thesis Prize 2024 and the Prof. Dr. J.Th.J. van den Berg-prijs 2024. Who authored the best thesis in Leiden University’s bachelor’s programme in Political Science?

Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…

This research project, that started in September 2008, aims to explore how personal and public memories of the Dutch Revolt in the seventeenth century evolved and interacted to create new political and cultural identities for the societies that eventually were to become the kingdoms of the Netherlands…

How do harrowing war experiences affect different generations? Students have made a video about poignant family stories. They interviewed other students and writer Dubravka Ugrešić. The premiere of the film was on 4 May during the online Hour of Remembrance. Watch this online memorial.

Lecture, China Seminar Series event

As a student or staff member at Leiden University, do you want to organise a meeting and invite an expert? We advise you to contact one of these institutes.

As one of the most influential ideas in modern European history, democracy has fundamentally reshaped not only the landscape of governance, but also social and political thought throughout the world.