This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.

Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.

How can zebrafish research help understanding human diseases?

By carrying out fundamental research and providing excellent education, universities become a breeding ground for innovation and entrepreneurship.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

Isotopes on exoplanets, a more efficient memory for data centres or new molecules that work against the Zika virus and HIV. Which PhD candidate has written the most impressive dissertation of 2023? The jury of the C.J. Kok Jury Award faces the challenging task of deciding that. Meet the nominees of…

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

The Faculty of Science is located at the Leiden Bio Science Park. It was founded more than two centuries ago and currently, more than 8000 people are working and studying at the eight institutes.

Premature babies almost always require treatment with medication. Doctors usually determine the dosages based on data from children who were not born prematurely, while preterm infants often develop differently. Medication researcher Aline Engbers investigated three commonly used drugs, focusing on…

Dutch archaeologists are making three-dimensional virtual reconstructions of archaeological objects lost in the Syrian civil war.

Polarisation in our society is on the rise. What makes people increasingly radical? How do we protect ourselves from extremist, terrorist or criminal threats, be they physical or in the cyber world? And what role do intelligence services play in this?

During the one-year master’s programme in Politics, Culture and National Identities, 1789 to the Present you will be studying an academic field that is an entirely new research area, putting you at the forefront of a new way of thinking about European history.

Frans Stoelinga defended his thesis on 19 November 2020.

The Journal of the LUCAS Graduate Conference was founded in 2013 to publish a selection of the best papers presented at the biennial LUCAS Graduate Conference, an international and interdisciplinary humanities conference organized by the Leiden University Centre for the Arts in Society (LUCAS). The…

Education in (Chinese) Medicinal Plants associated to the Hortus botanicus in Leiden - Which Traditional Chinese Medicinal plants can be grown in the Hortus? - Establishing of a database which Chinese medical plants are available in Dutch Botanical Gardens - Data validation (correct identification,…

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.

PhD candidates carry out a programme of independent research and additional limited) course work, culminating in production of a PhD thesis in typically 4 years.

There is considerable need for improved skin models to develop safe and efficient drugs for skin delivery as well as for cosmetic and chemical product testing on the skin.

The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

PhD at Leiden University and Bruker - the Netherlands

Can new variants of daptomycin and the polymyxins be found?

List of Support Departments at LION and the Faculty of Science

Promotor: M.A.G.J. Orrit

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The sentencing decision of the judge might be the most important decision in the criminal proceedings, not only because of the impact the punishment has on the offender, but also because the sentencing decision is a cornerstone of the legitimacy of the entire criminal justice system.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

In this project, we use social network analysis to analyze the behavior of users in online forums and associated marketplaces over time.

Developing robust and comprehensive analytical methods to size and quantify subvisible particles in biopharmaceutical products.

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

To achieve a more consistent and professional look in our scientific posters. A new template has been chosen. This design and its principal elements can be downloaded here.

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

The overall aim of CAM-PaC is to contribute to solving the socioeconomic and health challenges of PDAC by an integrative and systematic functional analysis of pancreatic cancer candidate genes. CAM-PaC will develop novel cellular and animal models, as well as novel strategies to analyse and integrate…

Promotor: Prof.dr. M. Danhof

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Natural product inspired antibiotics to address resistance

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.