Researchers are pulled in various, sometimes contradictory directions by the multiplication of performance metrics and new incentives to align with societal needs. Management structures, funding systems, and publication practices are increasingly influenced by pressures to promote only the highest quality…

PhD defence

Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.

Machine Learning is becoming a more and more substantial technology for industry.

We aim to create an innovative e-learning and virtual reality training that helps healthcare providers to optimize placebo effects and minimizes nocebo effects via their communication.

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

On this page you can find information about previous CCLS events.

Computers are capable of making incredibly accurate predictions on the basis of machine learning. In other words, these computers can learn without intervention once they have been pre-programmed by humans. At LIACS, we explore and push the borders of what a revolutionary new generation of algorithms…

A team of researchers from Leiden Institute of Advanced Computer Science (LIACS) recently hosted a big international conference (EMO 2023). At the conference, computer scientists discussed algorithms that are important in areas such as drug discovery, industrial production planning, and sustainable…

Computers are capable of making incredibly accurate predictions on the basis of machine learning. In other words, these computers can learn without intervention once they have been pre-programmed by humans. At LIACS, we explore and push the borders of what a revolutionary new generation of algorithms…

In this dissertation several settings in the Online Learning framework are studied. The first chapter serves as an introduction to the relevant settings in Online Learning and in the subsequent chapters new results and insights are given for both full-information and bandit information settings.

In the week of 16 – 21 September, an international group of more than 50 scientists met at the Many Criteria Optimization and Decision Analysis (MACODA) workshop. They discussed many-criteria optimization, which is the searching for optimal solutions when one has to consider a larger number of criteria.…

Leiden Professor Marc Koper will be carrying out research on the chemical process underlying tin coating in order to optimise the quality of tin coatings. He has been awarded a subsidy of 285,000 euros from the STW Technology Foundation and Tata Steel.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

The perfect ship is light and sleek for speed, but also needs to be strong and stable for safe sailing. These and other conflicting requirements make it difficult, even with a supercomputer, to find the ideal design. Computer scientist Roy de Winter has developed an algorithm that helps strike the perfect…

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

How can computers help design optimal buildings? PhD student Koen van der Blom makes algorithms that take into account all kinds of different architectural requirements, in order to reach the best compromise. And that is quite difficult: 'Algorithms do not automatically understand that a building that…

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)

This dissertation provides crucial but as yet missing empirical data on the tone accent opposition in the so-called

David Versluis successfully simulated an infant gut virtually. This is crucial for research on improvements in formula milk. Currently, such research primarily relies on diaper contents, which is not optimal. Versluis defended his doctoral thesis on April 23.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.

On September 15th a new series of lectures will start, the Joint Lectures on Evolutionary Algorithms (JoLEA). This series of events is aimed at disseminating the latest, top-quality research on EAs. The lectures will feature world-renowned speakers, local researchers, and PhD students.

NWO awarded a grant for novel research on Complex and Distributed Cyber-Physical Systems (CPS). The grant will fund a four-year research project in which they hope to devise a method to explore and find optimal designs for CPS. Todor Stefanov, Associate Professor at the Leiden Institute of Advanced…

This dissertation provides a formal description of the relationship between diatopic/diachronic micro-variation and phonologization through analysis of the phonetic/phonological properties of unstressed vowel reduction and vowel insertion in two Northern Italian dialects.

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Lecture, Seminar

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Lecture

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

Andrew de la Haije is Director of the Dutch branch of Xebia Consultancy Services, an internationally operating consultancy agency that coaches companies through digital transformation. He followed the executive master’s programme in Cyber Security and graduated with distinction.

The theme of the Opening of the Academy Year on 4 September was sustainability and how the university could take the lead as a change agent. How is it going about this and what else can it do? There was also room for a critical note.

Partly thanks to Roy de Winter, ship design and engineering company C-Job Naval Architects now develops optimal ships in a short time. The master's student Computer Science from Leiden developed the CEGO algorithm, which eliminates the classic design cycle and makes people in the maritime optimization…