281 search results for “lipid chair lent” in the Public website
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Chair of UN Studies in Peace and Justice
From 1 August 2018, Alanna O'Malley was appointed as Chair of United Nations Studies in Peace and Justice, focusing on the ‘lesser-known actors’ of the UN: women, the youth, the agents of informal diplomatic networks within the UN and actors from the Global South. This Special Chair has been created…
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents
BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…
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An ex vivo human skin model for studying skin barrier repair
In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.
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LUMC researchers: high levels of lipids in blood protect against allergies
People with relatively high levels of lipids in their blood are less likely to develop allergic conditions such as eczema and asthma. These lipids cause genes that play a key role in allergic reactions to be less active. Researchers from the Leiden University Medical Center (LUMC) have published an…
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Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Evolutionary molecular dynamics
This thesis introduces the concept of
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Launch Owada Chair
On 24 May 2022, the universities of Tokyo and Leiden organized a rotating chair named after Professor Hisashi Owada. The Owada Chair focused on the interaction between international law and international relations in an interdisciplinary perspective. Dominique Moïsi, a professor at Kings College London…
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New Kikkoman chair in Leiden
The Kikkoman chair is a new chair in Leiden sponsored by the Kikkoman Foundation and the Association of Friends of Asiatic Art. The chair will address the intercultural dynamics of Asia and Europe.
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Travelling through the body with graphene
For the first time researchers have succeeded in placing a layer of graphene on top of a stable fatty lipid monolayer. Surrounded by a protective shell of lipids, graphene could enter the body and function as a versatile sensor. The results are the first step towards such a shell, and have been published…
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Research lines
Current research at the Skin Barrier and Vaccination group.
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Astronomy on Tap
Explore our amazing universe from your local bar!
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New Owada chair in Leiden and Tokyo
The universities of Tokyo and Leiden are installing a rotating chair named after Professor Hisashi Owada. The Owada chair will focus on interaction between international law and international relations through interdisciplinary approaches. Dominique Moïsi, a professor at King’s College in London, will…
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The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.
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Fourth Session of the Owada Chair
The University of Tokyo hosted the 2024 edition of the Owada Chair. GTGC's Prof. dr. Jan Aart Scholte and Prof. dr. Eric De Brabandere attended the session in representation of Leiden University.
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Skin Barrier and Vaccination
The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Novel factors modulating AGC kinase signaling-controlled polar auxin transport
The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.
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The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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A novel biofilm for skin barrier repair of patients with atopic eczema
Atopic eczema is a skin disease with increasing incidence currently affecting 25% of the paediatric population. In atopic eczema the skin barrier function is reduced. This barrier is formed by the outermost layer of the skin called the stratum corneum (SC). The SC consists of terminally differentiated…
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Anjali PanditScience
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Sander WezenbergScience
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Revolutie of zinsbegoocheling?
Wordt het nog wat met de Arabische lente?
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Student projects
Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
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Leiden University considers establishing chair for Workplace Pride
The Faculty of Social and Behavioural Sciences at Leiden University is considering establishing a special chair for Workplace Pride. The professor appointed to this chair will study opportunities for improving the position of lesbian women, homosexual men, bisexuals and transgender people (LGBTs) in…
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Owada Chair should bring together nations, cultures and individuals
Dominique Moïsi, a professor at King’s College London, will be the first holder of the Owada chair. ‘In the present international context of polarisation and divisions within societies and amongst nations, any effort at bringing Asia and Europe closer to each other is truly important.’
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Helen Pluut new chair of Young Academy Leiden
Young Academy Leiden brings together young researchers, gives them a say in policymaking and fosters interdisciplinary collaboration. Chair Tom Louwerse is passing on the baton to Helen Pluut. ‘Sharing your knowledge and experience with colleagues from other faculties and institutes is so valuable.’…
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Physics implications of shape on biological function
Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.
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Development of formulation for treatment of Atopic Eczema
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Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Stratum corneum ceramide profiling in immune-mediated inflammatory skin diseases
This project is part of the Next Generation ImmunoDermatology (NGID) consortium, which focuses on the comprehensive phenotyping of six different immune-mediated inflammatory skin conditions. A common factor contributing to these diseases is a dysfunctional skin barrier. The skin barrier function is…
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Ferd Grapperhaus new Chair of the Board of Governors
The Board of Governors of Leiden University is pleased to announce that the outgoing Minister of Education, Culture and Science, Robbert Dijkgraaf, has appointed Professor F.B.J. (Ferd) Grapperhaus as the new Chair of the Board of Governors.
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Jan Sleutels is new chair of Humanities Lab
He is the chair of the Faculty Council, Director of Education at the Institute for Philosophy and a Fellow of the Leiden Teachers’ Academy, and was recently appointed for three years as chair of the Humanities Lab. This is the Honours College programme of the Faculty of Humanities for students of all…
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Natural deep eutectic solvents: A new green solvent from nature
- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?
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Dean and vice-chair of LUMC Board steps down
Prof. dr. Pancras Hogendoorn is stepping down as dean of the Faculty of Medicine and vice-chair of the Executive Board of Leiden University Medical Centre (LUMC). He is also resigning from all associated secondary posts. Hogendoorn has taken his decision in anticipation of the findings of an inquiry…
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Team 6 Quality assurance in education
In order to successfully implement the kernvisie, it is important to examine how we can improve the quality of our education.
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Team 3 Study supervision & matching
In order to better engage students in our education and offer demanding help to students to complete their studies, this team will work out which facilities should be set up for this purpose and what preconditions are needed.
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Personal chair in ‘Stress-related psychopathology’ for Bernet Elzinga
Clinical psychologist Bernet Elzinga has been appointed as Professor of a personal chair at the Faculty of Social and Behavioural Sciences. This professorship will contribute both nationally and internationally to the broader promotion of Leiden University in the field of stress and psychopathology.
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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Development of novel metabolomics and systems pharmacology methods
We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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Synthetic modification of fusogenic coiled-coil peptides
A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…