Promotor: P.D. Grünwald

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

In the Drug Research theme, we primarily work with rodents. Rodents, such as mice, are one of the most common laboratory animals. These small mammals are easily housed and exhibit a rapid rate of reproduction.

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

Promotor: P. Stevenhagen, Co-promotores: B. de Smit, F. Andreatta

Studying the underlying principles of the nature of language.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

A study on the utilisation of Iron Age rectangular structures and related depositional practices in the Low Countries

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

In recent years, the issue of mass tort litigation and the fair and efficient settlement and adjudication of mass torts has drawn increasing attention in academic discourse, legal practice and policy debates.

Promotor: A. Kros

Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

A comprehensive analysis of Nietzsche's conception of conflict and the way in which relations of struggle condition the organisation of complex systems (with a specific focus on the human psyche and the body politic).

‘It became very clear that Brazilian legislative policy was frail, obsolete and unreliable,’ says Felipe de Paula. He defended his dissertation on the limits and possibilities of legislative policy in Brazil on Tuesday 27 March 2018.

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Source: Eur J Med Chem (2015)

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

On 3 September 2019, Ilektra Antonaki defended her thesis 'Privatisations and golden shares: Bridging the gap between the State and the market in the area of free movement of capital in the EU'. The doctoral research was supervised by Prof. S.C.G. Van den Bogaert.

Our team consists of the following members.

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Doctoral Thesis

Willemijn Heeren has, together with dr. Lei He (Department of Linguistics, Tübingen & Center for Forensic Phonetics and Acoustics, Zürich), received a research grant from the International Association for Forensic Phonetics and Acoustics to start a pilot project on “Between-speaker variability in dynamic…

PhD defence

The main research theme in the group of Dennis Hetterscheid is to understand and mimic bioinorganic multi-electron processes that are relevant to our future energy infrastructure. Reduction of protons generates hydrogen that can be used as a chemical fuel. Alternatively to gaseous hydrogen, the reduction…

Research at the MCBIM group is comprised of the following research themes:

Dutch Title:

We have recently discovered that there are biological proteins that phase separate out of solution much the way oil will de-mix from water (see movie). These form dense, liquid-like phases called protein condensates.

Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

This project investigates the role of art in the public and academic debate on biosolar energy

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

This report investigates the different approaches in the authorization process of GMOs for commercial use in the European Union and the United States of America. Three main aspects are considered and analyzed as potential causes of differences in the authorization process of GMOs for commercial use.…

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

Alfons Chorus was the ‘founding father’ of Psychology in Leiden. His son Rogier Chorus recently obtained his PhD at Leiden University based on his biography of his father. He talked to his Leiden PhD supervisor Willem Heiser about his father’s innovations, his plagiarism and how he was misunderstood…

On November 16 a festschrift in honor of Dr Olivier Nieuwenhuyse was presented in a moving event at the Faculty of Archaeology. Professor Bleda Düring, a personal friend of Nieuwenhuyse, was one of the initiators. ‘If he had been here, he would have loved this book.’

For fifteen years, Recep Uysal carried out research on positive psychology in Turkey; it is even the subject of his PhD. That was until he had to flee Turkey and start again from scratch in the Netherlands. Re-entering the academic world was a challenge, but he rediscovered his love for the field in…

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

The mission of the Plant Sciences cluster is to contribute to the sustainable production of high-quality crops, flowers and high-value bio-based products, and to contribute to the maintenance and restoration of biodiversity in natural ecosystems. This is realised by generating fundamental knowledge…