The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Combined hormonal contraceptives (CHC) are associated with an increased risk of venous thromboembolism (VTE). In 2013, a review was published by the European Medicines Agency (EMA). In this review, the authors concluded that the risk of VTE varies by the type of progesterone in the CHC. Subsequently,…

On the 12th of November, Xander Vertegaal successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Xander on this achievement!

On the 12th of December, Eleanor Dutton successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Eleanor on this achievement.

The Centre for the Study of Political Parties and Representation (CSPPR) aims to serve as an interdisciplinary platform for scholars of Leiden University for research focusing on the historical and contemporary operation and functioning of political parties and political representation, with a particular…

From 1 August 2018, Alanna O'Malley was appointed as Chair of United Nations Studies in Peace and Justice, focusing on the ‘lesser-known actors’ of the UN: women, the youth, the agents of informal diplomatic networks within the UN and actors from the Global South. This Special Chair has been created…

How is social cognition shaped by our knowledge of language and stories?

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

This thesis attempts to establish a dialogue between the modern and the medieval traditions in logic, by means of ‘translations’ of the medieval logical theories into the modern framework of symbolic logic, i.e. formalizations.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Science, Institute of Biology Leiden (IBL)

The EU is struggling with labour shortages. Migrant workers and asylum seekers would be able to fill this gap and solve many of these problems. But, says economics professor Olaf van Vliet, the pros and cons regarding this dilemma need to be explicitly addressed. 'Now the message in campaigns focusses…

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

Promotor: Prof.dr. G.P. van Wezel

Wijnhaven is the pride of our The Hague campus. For the first time, three faculties jointly presented their programmes in this modern building. We asked the school leavers and students why they had come to the Student for a Day experience.

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.

The Organ Art of the first female German concert organist and Bremen Cathedral organist and

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Markus Davidsen defended his thesis on 16 October 2014

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

Sensational, is how Leiden Egyptologist Olaf Kaper described the discovery of two new chambers in the tomb of pharaoh Tutankhamun. He hopes that a second set of scans will confirm their presence unequivocally.

Currently, the bill ‘Wet versterking waarborgfunctie Awb’ (strengthening the guarantee function of the Dutch General Administrative Law Act) is in preparation. The bill is intended to strengthen the human dimension in the execution and administration of justice.

Promotores: J. Kok, M. Chaudron (Chalmers University)

The making of sacrifices seems part and parcel of any elite sportsperson’s life. Remarkably, the insights that we find in the current literature in social sport studies are not able to make sense of the references to sacrifice in the data that emerged in the context of this study on the social significance…

n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.

Promotor: Prof.dr. A.G.G.M. Tielens, Co-Promotor: J.B.R. Oonk

Lecture

The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.

It is one of the greatest archaeological mysteries of all times: the disappearance of a Persian army of 50,000 men in the Egyptian desert around 524 BC. Leiden Professor Olaf Kaper unearthed a cover-up affair and solved the riddle.

Een internationaal consortium onder leiding van Olaf van Vliet heeft een Horizon Europe subsidie van 3,4 miljoen euro gewonnen. In het onderzoek staat centraal hoe wereldwijde sociale veranderingen zoals migratie, digitalisering en de klimaattransitie de arbeidsmarkt beïnvloeden en wat daar de gevolgen…

Promotor: Prof.dr. E.F. Smets

What makes a good historian? When historians raise this question, as they have done for centuries, they often do so to highlight that certain personal attitudes or dispositions are indispensable or studying the past. Yet their vieuws on what virtues, skills or competencies historians need most differ…

Can we predict fluctuations in suicidal ideation in a person’s daily life, from hour to hour?

When it comes to languages and cultures, Leiden University is the university. The global expertise present places our university at the top. In Leiden and The Hague, we study languages and cultures from all regions of the world and from prehistory to the present day. In this way we create a broad view…

The ARTIVES project studies imaginaries of diversity portrayed by artists in Lisbon and Rotterdam in their films, performances and (oral) literature with the aim to explore their transgressive potential of opening up possibilities of thinking differently about migration-related diversity. Their stories…

The project seeks to explore the interplay of valuation and inequalities in science, using the interdisciplinary and planet-critical field of forest research as empirical case. It examines which/whose knowledge is recognised on what grounds, and how social dimensions like gender and geographical location…

This thesis describes a study from both a theoreticaL and an experimental point of view.

In recent years, the use of primary data in terrorism research has increased. In order to maximise the benefits of this trend, we want to encourage terrorism scholars to implement open science practices more systematically. This article therefore presents different avenues towards open and reproducible…

In this article, Lianne Visser contributed to the understanding of why collaborative governance is a challenging response to wicked problems.

Sociaaleconomisch Beleid: Empirische Analyse is a new course for those students on the Bachelor’s programme in Public Administration who are following the specialisation in Economics, Administration and Management.

As part of Nexus 1492 Subproject 4: A Future for Diverse Caribbean Heritages, which seeks to shed light on how local communities interpret and engage with heritage in the present day, this doctoral study aims to gain insight into how indigenous heritage is represented in the school curriculum for social…

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Promotor: Prof.dr. R.M.H. Merks